Potential Drug Target and Biomarker for KCND3L (G3752)

Target Name: KCND3

NCBI ID: G3752

KCND3

Potential Drug Target and Biomarker for KCND3L

KCND3 (KCND3L) is a protein that is expressed in various tissues of the body, including the brain, heart, and kidneys. It is a member of the conditioned to contact DNA family, which is characterized by the presence of a specific DNA-binding domain in the protein. KCND3L is of particular interest as a potential drug target or biomarker due to its unique structure and the involvement of this family in various physiological processes.

Structure and Function

KCND3L is a 21-kDa protein that consists of 116 amino acid residues. It has a characteristic Rossmann-fold, which is a type of alpha-helices that are commonly found in proteins that interact with DNA. This structure allows KCND3L to bind to specific DNA sequences with high affinity. Additionally, KCND3L has a distinct N-terminus and a C-terminus, which are involved in the formation of the protein-DNA complex.

KCND3L functions as a transcription factor, which plays a crucial role in the regulation of gene expression. It is specifically involved in the development and maintenance of neural stem cells, which are a source of cells for regenerative medicine. KCND3L is also involved in the regulation of stem cell proliferation and the establishment of tissue niches.

Drug Target Potential

KCND3L is a potential drug target due to its unique structure and the involvement of this family in various physiological processes. The high affinity of KCND3L for DNA sequences makes it an attractive target for small molecules that can modulate gene expression. Additionally, the involvement of KCND3L in neural stem cell development and maintenance makes it an attractive target for drugs that are effective in these conditions.

Biomarker Potential

KCND3L is also a potential biomarker for various diseases, including cancer. The regulation of neural stem cells and their differentiated derivatives is a critical aspect of cancer development, and alterations in this process can be used as a biomarker for cancer. KCND3L is involved in the regulation of stem cell proliferation and the establishment of tissue niches, and therefore, changes in its expression levels can be used as a biomarker for cancer.

Conclusion

KCND3L is a protein that is expressed in various tissues of the body and is involved in various physiological processes, including the regulation of neural stem cells and their differentiated derivatives. Its unique structure and the involvement of this family in various processes make it an attractive target for small molecules and a potential biomarker for cancer. Further research is needed to fully understand the role of KCND3L as a drug target and biomarker.

Protein Name: Potassium Voltage-gated Channel Subfamily D Member 3

Functions: Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium channels. May contribute to I(To) current in heart and I(Sa) current in neurons. Channel properties are modulated by interactions with other alpha subunits and with regulatory subunits

The "KCND3 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about KCND3 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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