Understanding KCNK4: Potential Drug Targets and Biomarkers (G50801)

Target Name: KCNK4

NCBI ID: G50801

KCNK4

Understanding KCNK4: Potential Drug Targets and Biomarkers

KCNK4 is a protein that is expressed in many different tissues and cells in the human body. It is a member of the subfamily K of the potassium channels, which are a family of transmembrane proteins that play a crucial role in the regulation of ion channels in various biological processes. In this article, we will discuss the potential drug targets and biomarkers associated with KCNK4, as well as its structure, function, and potential therapeutic applications.

Structure and Function

KCNK4 is a 22kDa protein that is expressed in a variety of tissues, including cardiac muscle, skeletal muscles, nerve fibers, and brain. It is a member of the subfamily K of the potassium channels, which are characterized by the presence of a variable region of 120 amino acids that is involved in the regulation of the channel's conductivity. The variable region includes four unique amino acids that are involved in the regulation of the channel's conductivity and stability.

One of the unique features of KCNK4 is its ability to regulate the activity of other ion channels. This is accomplished through the interaction of the protein with the ion channels, as well as through the regulation of the activity of other proteins that interact with the channel . For example, studies have shown that KCNK4 can regulate the activity of the Na+, K+, and Ca2+ channels, as well as the Ca2+-ATPase enzyme.

KCNK4 has also been shown to play a role in the regulation of muscle contractions. Studies have shown that the activity of KCNK4 is highly dependent on the levels of calcium ions in the muscle fibers. When calcium ions are present, the activity of KCNK4 is activated , leading to the regulation of muscle contractions. This interaction between KCNK4 and calcium ions is important for the proper functioning of muscle cells, and is potentially therapeutic in the treatment of muscle-related diseases.

Drug Targets and Biomarkers

KCNK4 is a potential drug target for a variety of conditions. The regulation of ion channels by KCNK4 is disrupted in a number of diseases, including epilepsy, myocardial infarction, and myopathies. The ability of KCNK4 to regulate the activity of other ion channels also makes it is a potential biomarker for these conditions.

One of the most promising potential drug targets for KCNK4 is the treatment of epilepsy. KCNK4 has been shown to regulate the activity of the EPS1 gene, which encodes the EPS1 protein. The EPS1 protein is involved in the regulation of ion channels, including those in the nervous system. The disruption of ion channel regulation by EPS1 has been implicated in the pathophysiology of epilepsy.

Another potential drug target for KCNK4 is the treatment of heart disease. KCNK4 has been shown to regulate the activity of the myosin ATPase (MAA) enzyme, which is involved in the regulation of muscle contractions. The disruption of ion channel regulation by MAA has been implicated in the pathophysiology of heart disease.

In addition to its potential therapeutic applications, KCNK4 is also a potential biomarker for a variety of conditions. The regulation of ion channels by KCNK4 is disrupted in a number of diseases, including epilepsy, myocardial infarction, and myopathies. The ability of KCNK4 to regulate the activity of other ion channels also makes it a potential biomarker for these conditions.

Conclusion

In conclusion, KCNK4 is a protein that is expressed in many different tissues and cells in the human body. It is a member of the subfamily K of the potassium channels, and is involved in the regulation of ion channels in various biological processes. In this article, we have discussed the potential drug targets and biomarkers associated with KCNK4, as well as its structure, function, and potential therapeutic applications. Further research is needed to fully understand the role of KCNK4 in the regulation of ion channels and its potential as a drug

Protein Name: Potassium Two Pore Domain Channel Subfamily K Member 4

Functions: Voltage-insensitive potassium channel (PubMed:22282805). Channel opening is triggered by mechanical forces that deform the membrane (PubMed:22282805, PubMed:25471887, PubMed:25500157, PubMed:30290154). Channel opening is triggered by raising the intracellular pH to basic levels (By similarity). The channel is inactive at 24 degrees Celsius (in vitro); raising the temperature to 37 degrees Celsius increases the frequency of channel opening, with a further increase in channel activity when the temperature is raised to 42 degrees Celsius (By similarity). Plays a role in the perception of pain caused by heat (By similarity). Plays a role in the sensory perception of pain caused by pressure (By similarity)

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