KCNC2: Key Player in Intracellular Transport System (G3747)

Target Name: KCNC2

NCBI ID: G3747

KCNC2

Other Name(s): DEE103 | Potassium voltage-gated channel subfamily C member 2, transcript variant 6 | Potassium voltage-gated channel subfamily C member 2 (isoform KV3.2b) | Potassium voltage-gated channel subfamily C member 2 (isoform KV3.2d) | Potassium voltage-gated channel subfamily C member 2, transcript variant 1 | voltage-gated potassium channel Kv3.2 | KCNC2 variant 5 | Potassium voltage-gated channel subfamily C member 2 (isoform 4) | Potassium voltage-gated channel subfamily C member 2 (isoform 6) | KV3.2 | KV3.2a | Potassium voltage-gated channel subfamily C member 2 (isoform KV3.2a) | Voltage-gated potassium channel Kv3.2 | Potassium voltage-gated channel subfamily C member 2, transcript variant 3 | shaw-like potassium channel | Shaw-like potassium channel | Kv3.2 | potassium voltage-gated channel, Shaw-related subfamily, member 2 | Potassium channel, voltage gated Shaw related subfamily C, member 2 | KCNC2 variant 4 | KCNC2 variant 6 | KCNC2 variant 3 | Potassium voltage-gated channel subfamily C member 2 (isoform KV3.2c) | potassium channel, voltage gated Shaw related subfamily C, member 2 | Potassium voltage-gated channel subfamily C member 2 | KCNC2 variant 1 | KCNC2 variant 2 | Potassium voltage-gated channel subfamily C member 2, transcript variant 4 | KCNC2_HUMAN | potassium voltage-gated channel subfamily C member 2 | KV3.2b | Potassium voltage-gated channel subfamily C member 2, transcript variant 5 | Potassium voltage-gated channel subfamily C member 2, transcript variant 2 | Potassium voltage-gated channel, Shaw-related subfamily, member 2

KCNC2: Key Player in Intracellular Transport System

KCNC2 (Kinesin-2) is a protein that is expressed in almost all human tissues and is involved in the intracellular transport of various molecules, including small molecules, ions, and cells. It is a key player in the intracellular transport system, which is responsible for moving large molecules and cells throughout the cell.

KCNC2 is a member of the Kinesin family of proteins, which are known for their ability to transport molecules through the cell membrane. Different types of Kinesins have different mechanisms for transport, but all of them share the same general structure. The Kinesin-2 protein is composed of a long amino acid sequence that is held together by a tertiary structure. This structure consists of a catalytic center, which contains a nucleotide base, as well as a transmembrane region and an intracellular region.

The catalytic center is the site where the Kinesin-2 protein uses its ATP-dependent motors to transport molecules across the cell membrane. The transmembrane region is responsible for the protein's ability to bind to the cell surface and the intracellular region is responsible for the protein's ability to transport molecules within the cell.

KCNC2 is involved in many different cellular processes, including the transport of small molecules, ions, and cells. It is also involved in the regulation of cell growth, differentiation, and apoptosis.

One of the main functions of KCNC2 is its role in the regulation of cell growth and differentiation. It is well known that Kinesin-2 is involved in the transport of neurons during the development and progression of the nervous system. Studies have shown that mice that are genetically modified to lack the Kinesin-2 protein have altered neural development and behavior.

KCNC2 is also involved in the regulation of cell apoptosis. Research shows that Kinesin-2 is involved in the delivery of apoptotic cells to the cell surface, where they can be engulfed by macrophages and other intracellular immune cells. This is important for the regulation of cell death, as it helps to remove damaged or dysfunctional cells from the body.

Another function of KCNC2 is its role in the regulation of ion transport. Ions are essential for many different cellular processes, including muscle contractions, nerve function, and cell signaling. KCNC2 is involved in the transport of ions across the cell membrane, ensuring that they are able to perform their intended functions.

In addition to its role in the regulation of cell growth, differentiation, and apoptosis, KCNC2 is also involved in the regulation of many other cellular processes. For example, it is involved in the transport of small molecules that are used for cellular signaling, such as growth factors and neurotransmitters. It is also involved in the transport of cells that are involved in the immune response, such as T cells and natural killer cells.

Overall, KCNC2 is a protein that is involved in many different cellular processes. Its role in the regulation of cell growth, differentiation, and apoptosis, as well as its involvement in the transport of small molecules and ions, make it an attractive drug target for researchers. Further studies are needed to fully understand the functions of KCNC2 and its potential as a drug.

Protein Name: Potassium Voltage-gated Channel Subfamily C Member 2

Functions: Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain. Contributes to the regulation of the fast action potential repolarization and in sustained high-frequency firing in neurons of the central nervous system. Homotetramer channels mediate delayed-rectifier voltage-dependent potassium currents that activate rapidly at high-threshold voltages and inactivate slowly. Forms tetrameric channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane (PubMed:15709110). Can form functional homotetrameric and heterotetrameric channels that contain variable proportions of KCNC1, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel. Channel properties may be modulated either by the association with ancillary subunits, such as KCNE1, KCNE2 or KCNE3 or indirectly by nitric oxide (NO) through a cGMP- and PKG-mediated signaling cascade, slowing channel activation and deactivation of delayed rectifier potassium channels (By similarity). Contributes to fire sustained trains of very brief action potentials at high frequency in retinal ganglion cells, thalamocortical and suprachiasmatic nucleus (SCN) neurons and in hippocampal and neocortical interneurons (PubMed:15709110). Sustained maximal action potential firing frequency in inhibitory hippocampal interneurons is negatively modulated by histamine H2 receptor activation in a cAMP- and protein kinase (PKA) phosphorylation-dependent manner. Plays a role in maintaining the fidelity of synaptic transmission in neocortical GABAergic interneurons by generating action potential (AP) repolarization at nerve terminals, thus reducing spike-evoked calcium influx and GABA neurotransmitter release. Required for long-range synchronization of gamma oscillations over distance in the neocortex. Contributes to the modulation of the circadian rhythm of spontaneous action potential firing in suprachiasmatic nucleus (SCN) neurons in a light-dependent manner (By similarity)

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