KCNQ2: A Potential Drug Target Or Biomarker (G3785)

Target Name: KCNQ2

NCBI ID: G3785

KCNQ2

KCNQ2: A Potential Drug Target Or Biomarker

KCNQ2, a member of the KQT subfamily of voltage-gated potassium channels, is a protein that plays a crucial role in many cellular processes. It is highly expressed in various tissues, including cardiac muscle, neurons, and epithelial cells, and is involved in Various physiological functions, including muscle contractions, neurotransmitter release, and cell signaling.

KCNQ2 has also been identified as a potential drug target or biomarker, which could be useful for the development of new therapies for various diseases. In this article, we will discuss the structure and function of KCNQ2, its potential drug-target properties, and the current research on this protein.

Structure and Function

KCNQ2 is a member of the KQT subfamily of voltage-gated potassium channels, which are a family of transmembrane proteins that play a central role in electrical signaling. These channels are characterized by the presence of a voltage-gated ion channel that can conduct alternating current (AC) in response to changes in the membrane potential.

KCNQ2 is a 21-kDa protein that consists of 120 amino acid residues. It has a unique structure that is composed of a catalytic alpha-helices, which are responsible for the channel's voltage-gated properties, and a carboxy-terminal region, which is involved in the interaction with other proteins.

Function

KCNQ2 is involved in various physiological processes, including muscle contractions, neurotransmitter release, and cell signaling. In muscle cells, KCNQ2 is involved in the regulation of muscle contractions, which are essential for movement and maintaining posture. During muscle contractions, KCNQ2 helps to generate the rapid, rapid changes in membrane potential that are necessary for muscle cell contraction.

KCNQ2 is also involved in neurotransmitter release, which is critical for the transmission of signals in the nervous system. When neurons receive neurotransmitters, they need to release these transmitters through KCNQ2 channels. This process is important for communication and regulation between neurons.

KCNQ2 is also involved in cell signaling, which is the process by which cells communicate with each other and with their surroundings. In many cases, these signaling processes are critical for cell survival and growth. KCNQ2 plays a role in several signaling pathways, including the regulation of cell proliferation and the response to environmental stimuli.

Potential Drug Targets

KCNQ2 has been identified as a potential drug target or biomarker due to its unique structure and function. The high expression level of KCNQ2 in various tissues, including cardiac muscle, neurons, and epithelial cells, makes it an attractive target for drug developers.

One of the reasons for the potential of KCNQ2 as a drug target is its involvement in various signaling pathways. Its involvement in these pathways makes it a potential target for drugs that can modulate its function and activity. Additionally, the unique structure of KCNQ2 makes it difficult to predict the effects of drugs that interact with it, which could make it an even more attractive target.

Another reason for the potential of KCNQ2 as a drug target is its location in the cell membrane. Its location in the middle of the cell membrane makes it an attractive target for drugs that can disrupt its function and localization.

Current Research

Current research on KCNQ2 is focused on its potential as a drug target or biomarker. There is a growing interest in developing new therapies for various diseases that target KCNQ2.

One of the most promising strategies for targeting KCNQ2 is the use of small molecules that can modulate its function and activity. Researchers have identified several small molecules that have been shown to interact with KCNQ2 and enhance its function. These molecules include benzodiazepines, which are commonly used

Protein Name: Potassium Voltage-gated Channel Subfamily Q Member 2

Functions: Associates with KCNQ3 to form a potassium channel with essentially identical properties to the channel underlying the native M-current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons as well as the responsiveness to synaptic inputs. Therefore, it is important in the regulation of neuronal excitability. KCNQ2/KCNQ3 current is blocked by linopirdine and XE991, and activated by the anticonvulsant retigabine (PubMed:9836639, PubMed:11572947, PubMed:14534157, PubMed:12742592, PubMed:17872363). As the native M-channel, the potassium channel composed of KCNQ2 and KCNQ3 is also suppressed by activation of the muscarinic acetylcholine receptor CHRM1 (PubMed:10684873). KCNQ2-KCNQ3 channel is selectively permeable to other cations besides potassium, in decreasing order of affinity K(+) > Rb(+) > Cs(+) > Na(+). Associates with Na(+)-coupled myo-inositol symporter SLC5A3 forming a coregulatory complex that alters ion selectivity, increasing Na(+) and Cs(+) permeation relative to K(+) permeation

The "KCNQ2 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about KCNQ2 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets