Exploring the Potential Drug Target and Biomarker for KCNN4: A Potassium Ca2+-Activated Channel Subfamily N Member 4

Target Name: KCNN4

NCBI ID: G3783

KCNN4

Exploring the Potential Drug Target and Biomarker for KCNN4: A Potassium Ca2+-Activated Channel Subfamily N Member 4

Introduction

KCNN4, a member of the potassium calcium-activated channel subfamily N, has been identified as a potential drug target and biomarker for various neurological and cardiovascular diseases. This subfamily of channels is involved in the regulation of neuronal excitability and provide a critical signaling pathway in the nervous system. Activation of these channels can lead to rapid and robust muscle contractions, which are essential for movement and maintaining posture. On the other hand, imbalances in their activity can lead to muscle weakness, paralysis, and even death.

Several studies have identified KCNN4 as a promising drug target for various neurological disorders, including Alzheimer's disease, Parkinson's disease, and Huntington's disease. These disorders are characterized by the progressive loss of brain cells and progressive muscle weakness, which can lead to significant improvements in patients ' quality of life. By targeting KCNN4, researchers aim to develop new treatments that can slow down or even reverse the degenerative effects of these disorders.

In addition to its potential therapeutic applications, KCNN4 has also been identified as a potential biomarker for these disorders. The accuracy and reliability of these biomarkers can have a significant impact on the development and progression of these diseases. They can help doctors to diagnose, monitor , and treat the diseases at an early stage, which can significantly improve patient outcomes.

Understanding KCNN4: Structure, Functions, and Interactions

KCNN4 is a member of the potassium calcium-activated channel subfamily N, which is a well-established family of channels that play a crucial role in the regulation of neuronal excitability. These channels are involved in the rapid and robust muscle contractions that are essential for movement and maintaining posture. They are also involved in the regulation of pain perception and the modulation of neurotransmitter release.

The structure of KCNN4 is characterized by a unique arrangement of multiple transmembrane segments and a characteristic ion selectivity that allows it to regulate the entry of different types of ions. The channel is composed of a variable number of subunits, which can form pairs or trimers. These subunits are held together by ionic bonds, and the channel has a unique voltage-dependent ion channel (VDIC) mechanism that allows it to regulate the flow of ions through.

KCNN4 functions as a channel that plays a critical role in the regulation of neuronal excitability and the modulation of ion channels. It is involved in the regulation of muscle contractions, pain perception, and neurotransmitter release.

KCNN4 Interactions

KCNN4 is involved in several interactions that are essential for its function. These interactions include:

1. Ion selectivity: KCNN4 has a unique ion selectivity that allows it to regulate the entry of different types of ions. It can bind to positively charged ions, negatively charged ions, or even a combination of both. This ion selectivity is critical for maintaining the stability and integrity of the channel and for the regulation of the conductivity of the channel.
2. Voltage-dependent ion channel (VDIC) mechanism: KCNN4 has a VDIC mechanism that allows it to regulate the flow of ions through the channel. This mechanism is based on the regulation of the voltage at the surface of the channel, which is known as the \"open\" or \"closing\" potential. When the voltage is increased, the channel is opened, and the ions can flow through. When the voltage is decreased, the channel is closed, and the ions cannot flow through.
3. Peaceful effect: KCNN4 can also have a peaceful effect, which means that it can regulate the activity of other ion channels. This peaceful effect can be either positive or negative, and it depends on the type of ion channel that is being regulated.

Potential Drug Targets

KCNN4 has been identified as a

Protein Name: Potassium Calcium-activated Channel Subfamily N Member 4

Functions: Forms a voltage-independent potassium channel that is activated by intracellular calcium (PubMed:26148990). Activation is followed by membrane hyperpolarization which promotes calcium influx. Required for maximal calcium influx and proliferation during the reactivation of naive T-cells (PubMed:17157250, PubMed:18796614). Plays a role in the late stages of EGF-induced macropinocytosis (PubMed:24591580)

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•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
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•   the target screening and validation;
•   expression level;
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•   related combination drugs;
•   pharmacochemistry experiments;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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