Understanding and Targeting KCNK13 (G56659)

Target Name: KCNK13

NCBI ID: G56659

KCNK13

Understanding and Targeting KCNK13

KCNK13 (K2P13.1 potassium channel), also known as human transient receptor potential cation channels subfamily K member 13.1, is a protein that plays a crucial role in various physiological processes in the body. It is a member of the transient receptor potential (TRP ) gene family, which encodes for proteins that can sense changes in chemical environment and regulate various physiological processes. This protein is expressed in many different tissues and cells in the body, including muscle, heart, and neurotransmitter-producing cells.

KCNK13 functions as a potassium channel, allowing it to regulate the movement of positively charged ions, such as calcium and magnesium, into and out of cells. This process is essential for maintaining the resting membrane potential of the cell, as well as the transmembrane potential of the channel. In addition to its role in ion transport, KCNK13 is also involved in several other cellular processes, including cell signaling, neurotransmission, and pain perception.

Drugs that target KCNK13 have been shown to be effective in treating a variety of neurological and psychiatric disorders, including epilepsy, migraine, and anxiety. In addition, modulation of KCNK13 activity has also been suggested as a potential therapeutic approach for treating certain types of cancer.

KCNK13 is a transmembrane protein that is composed of four conserved domains: an N-terminus, a catalytic domain, a Regulatory domain, and a C-terminus. The N-terminus of KCNK13 is responsible for its ability to bind to intracellular signaling molecules, such as neurotransmitters and ion channels. The catalytic domain is the region of the protein that is involved in the electrochemical mechanism of the channel, allowing it to mediate the movement of positively charged ions. The Regulatory domain is responsible for the regulation of channel function, and the C-terminus is the region that interacts with other proteins and molecules, such as the channels' intracellular signaling partners.

KCNK13 is a versatile protein that plays a critical role in many cellular processes. Its ability to regulate ion transport and participate in signaling pathways makes it an attractive drug target for a variety of disorders. The potential therapeutic benefits of modulating KCNK13 activity are vast, and continue to be explored by researchers.

Conclusion

KCNK13 is a protein that is involved in various cellular processes that are essential for maintaining the health and function of the body. As a member of the TRP gene family, it is a potential drug target for a variety of neurological and psychiatric disorders. Its role as a potassium channel and its involvement in signaling pathways make it an attractive target for the development of new treatments for a variety of disorders. Further research is needed to fully understand the molecular mechanisms underlying the function of KCNK13 and to explore its potential as a therapeutic approach.

Protein Name: Potassium Two Pore Domain Channel Subfamily K Member 13

Functions: Potassium channel displaying weak inward rectification in symmetrical K(+) solution

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