Understanding Twik-1: A Protein Involved in Cell Signaling, Protein Synthesis, DNA Replication

Target Name: KCNK1

NCBI ID: G3775

KCNK1

Understanding Twik-1: A Protein Involved in Cell Signaling, Protein Synthesis, DNA Replication

KCNK1 (TWIK-1) is a protein that is expressed in various tissues throughout the body, including the brain, heart, kidneys, and liver. It is a member of the馃槈 family of proteins, which are known as the Twik-1 family. Twik-1 proteins are involved in a variety of cellular processes, including cell signaling, DNA replication, and protein synthesis.

One of the unique features of Twik-1 is its ability to form a binary complex with other proteins. This allows Twik-1 to interact with other proteins and molecules in a targeted and precise manner, which is important for many cellular processes. For example, Twik-1 has been shown to form a binary complex with the protein p21, which is a key regulator of the cell cycle. This interaction between Twik-1 and p21 has been shown to play a role in regulating cell cycle progression and cell growth.

Another important function of Twik-1 is its role in the regulation of protein synthesis. Twik-1 has been shown to interact with the protein FSRN, which is involved in the translation of RNA into protein. This interaction between Twik-1 and FSRN has been shown to regulate the amount of protein produced by the cell, which is important for many cellular processes, including cell signaling and growth.

In addition to its role in protein synthesis and cell signaling, Twik-1 is also involved in the regulation of DNA replication. Twik-1 has been shown to interact with the protein DnaF, which is involved in the repair of DNA damage. This interaction between Twik-1 and DnaF has been shown to play a role in regulating the process of DNA replication in the cell.

Overall, Twik-1 is a protein that is involved in a variety of cellular processes, including cell signaling, protein synthesis, DNA replication, and other functions. Its unique ability to form binary complex with other proteins, as well as its involvement in the regulation of these processes, makes Twik-1 an attractive drug target or biomarker. Further research is needed to fully understand the role of Twik-1 in the cell and its potential as a drug.

Protein Name: Potassium Two Pore Domain Channel Subfamily K Member 1

Functions: Ion channel that contributes to passive transmembrane potassium transport and to the regulation of the resting membrane potential in brain astrocytes, but also in kidney and in other tissues (PubMed:15820677, PubMed:21653227). Forms dimeric channels through which potassium ions pass in accordance with their electrochemical gradient. The channel is selective for K(+) ions at physiological potassium concentrations and at neutral pH, but becomes permeable to Na(+) at subphysiological K(+) levels and upon acidification of the extracellular medium (PubMed:21653227, PubMed:22431633). The homodimer has very low potassium channel activity, when expressed in heterologous systems, and can function as weakly inward rectifying potassium channel (PubMed:8605869, PubMed:8978667, PubMed:15820677, PubMed:21653227, PubMed:22431633, PubMed:23169818, PubMed:25001086). Channel activity is modulated by activation of serotonin receptors (By similarity). Heterodimeric channels containing KCNK1 and KCNK2 have much higher activity, and may represent the predominant form in astrocytes (By similarity). Heterodimeric channels containing KCNK1 and KCNK3 or KCNK9 have much higher activity (PubMed:23169818). Heterodimeric channels formed by KCNK1 and KCNK9 may contribute to halothane-sensitive currents (PubMed:23169818). Mediates outward rectifying potassium currents in dentate gyrus granule cells and contributes to the regulation of their resting membrane potential (By similarity). Contributes to the regulation of action potential firing in dentate gyrus granule cells and down-regulates their intrinsic excitability (By similarity). In astrocytes, the heterodimer formed by KCNK1 and KCNK2 is required for rapid glutamate release in response to activation of G-protein coupled receptors, such as F2R and CNR1 (By similarity). Required for normal ion and water transport in the kidney (By similarity). Contributes to the regulation of the resting membrane potential of pancreatic beta cells (By similarity). The low channel activity of homodimeric KCNK1 may be due to sumoylation (PubMed:15820677, PubMed:20498050, PubMed:23169818). The low channel activity may be due to rapid internalization from the cell membrane and retention in recycling endosomes (PubMed:19959478)

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