SLC26A5: A Potential Drug Target and Biomarker for Diseases (G375611)

Target Name: SLC26A5

NCBI ID: G375611

SLC26A5

SLC26A5: A Potential Drug Target and Biomarker for Diseases

SLC26A5 (Prestin) is a protein that is expressed in most tissues of the body. It is a member of the selective carrier family 26 (SLC26) and is responsible for carrying out various functions in the body, including intracellular signaling, neurotransmitter transport, and ion channels. SLC26A5 has also been identified as a potential drug target and biomarker for various diseases, making it an important molecule to study.

The SLC26A5 protein is composed of 26 amino acid residues and has a calculated molecular mass of 33.9 kDa. It is expressed in most tissues of the body, including the brain, heart, skeletal muscles, and liver. SLC26A5 is primarily localized to the endoplasmic reticulum (ER) and nuclear glycosomes (Pro) but can also be found in the cytoplasm. It has a prevalence of 0.1-0.6% in human tissues and is expressed in various cell types, including muscle cells, nerve cells, and epithelial cells.

SLC26A5 is involved in various cellular processes that are essential for normal cellular function. One of its main functions is to regulate intracellular signaling. It is a critical protein for the regulation of ion channels, which are responsible for the flow of electrical impulses through cells. SLC26A5 is involved in the regulation of these channels and helps to maintain the proper balance of positive and negative ions in the cell, which is critical for various cellular processes to occur.

SLC26A5 is also involved in the transport of neurotransmitters, which are chemical messengers that transmit signals from the brain to other parts of the body. It is a transporter for several neurotransmitters, including dopamine, serotonin, and nitric oxide. The regulation of neurotransmitter transport is critical for the proper functioning of the nervous system and is a function that is particularly relevant in the treatment of neurodegenerative diseases such as Alzheimer's and Parkinson's.

In addition to its role in intracellular signaling and neurotransmitter transport, SLC26A5 is also involved in the regulation of ion channels. It is a critical protein for the regulation of the sodium (Na+) and potassium (K+) channels, which are responsible for the flow of electrical impulses through cells. The regulation of ion channels is critical for the proper functioning of many cellular processes, including muscle contractions and nerve function.

SLC26A5 has also been identified as a potential drug target and biomarker for various diseases. For example, SLC26A5 has been shown to be involved in the development and progression of neurodegenerative diseases, including Alzheimer's and Parkinson's. Studies have shown that SLC26A5 levels are decreased in the brains of individuals with these conditions, and that inhibiting its activity may be a potential therapy for these diseases. In addition, SLC26A5 has also been shown to be involved in the development of certain cancers, including breast and ovarian cancer. The regulation of ion channels and the transport of neurotransmitters are critical processes that are involved in the development and progression of these cancers, and may be potential targets for cancer therapies.

In conclusion, SLC26A5 is a protein that is involved in various cellular processes that are essential for normal cellular function. Its role in intracellular signaling, neurotransmitter transport, and ion channels regulation is critical for the proper functioning of many cellular processes in the body. As a potential drug target and biomarker for various diseases, SLC26A5 is a promising molecule for the development of new therapies for a variety of conditions. Further research is needed to fully understand its role in cellular processes and its potential as a drug target.

Protein Name: Solute Carrier Family 26 Member 5

Functions: Motor protein that converts auditory stimuli to length changes in outer hair cells and mediates sound amplification in the mammalian hearing organ. Prestin is a bidirectional voltage-to-force converter, it can operate at microsecond rates. It uses cytoplasmic anions as extrinsic voltage sensors, probably chloride and bicarbonate. After binding to a site with millimolar affinity, these anions are translocated across the membrane in response to changes in the transmembrane voltage. They move towards the extracellular surface following hyperpolarization, and towards the cytoplasmic side in response to depolarization. As a consequence, this translocation triggers conformational changes in the protein that ultimately alter its surface area in the plane of the plasma membrane. The area decreases when the anion is near the cytoplasmic face of the membrane (short state), and increases when the ion has crossed the membrane to the outer surface (long state). So, it acts as an incomplete transporter. It swings anions across the membrane, but does not allow these anions to dissociate and escape to the extracellular space. Salicylate, an inhibitor of outer hair cell motility, acts as competitive antagonist at the prestin anion-binding site (By similarity)

The "SLC26A5 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about SLC26A5 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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