Unlocking The Potential of ARF5: A Protein Targeted for Drug Development and Biomarker Use

Target Name: ARF5

NCBI ID: G381

ARF5

Other Name(s): ARF5_HUMAN | ADP-ribosylation factor 5 | ADP ribosylation factor 5

Unlocking The Potential of ARF5: A Protein Targeted for Drug Development and Biomarker Use

ARF5 (ARF5-HUMAN) is a protein that is expressed in human tissues and has been identified as a potential drug target or biomarker. It is a member of the ARF5 gene family, which is known for its role in cell signaling pathways. ARF5 is expressed in a variety of human tissues, including muscle, heart, and brain, and has been shown to play a role in the regulation of cellular processes such as cell adhesion, migration, and survival.

One of the key challenges in studying ARF5 is its complex structure. ARF5 is a 21-kDa protein that consists of an N-terminal transmembrane domain, a coiled-coil region, and an C-terminal T-loop. The transmembrane domain is thought to play a key role in the protein's ability to interact with intracellular signaling pathways, while the coiled-coil region is believed to contribute to the protein's stability and localization in the cell. The T-loop is also thought to play a structural role in the protein's stability.

While much research has been done on ARF5, much of its biology remains un understood. One of the key challenges is its complex interactions with other proteins. ARF5 has been shown to interact with a variety of intracellular signaling pathways, including the TGF-β pathway, the PI3K/Akt pathway, and the NF-kappa-B pathway. It is also thought to play a role in the regulation of cellular processes such as cell adhesion, migration, and survival.

One of the potential drug targets for ARF5 is its role in the regulation of cell adhesion. ARF5 has been shown to play a role in the regulation of cell-cell adhesion in various tissues, including muscle and heart cells. It is thought to interact with proteins such as E-cadherin, a protein that is involved in cell-cell adhesion, and can inhibit the activity of smooth muscle contractions. This suggests that ARF5 may be a useful target for drugs that are designed to modulate cell-cell adhesion.

Another potential drug target for ARF5 is its role in the regulation of cell migration. ARF5 has been shown to play a role in the regulation of cell migration in various tissues, including cancer cells. It is thought to interact with proteins such as the transcription factor NF-kappa-B and the protein PDGFR-尾, both of which are involved in cell migration. This suggests that ARF5 may be a useful target for drugs that are designed to inhibit cell migration.

In addition to its potential drug targets, ARF5 also has potential as a biomarker. Because it is expressed in a variety of human tissues, it may be a useful protein to use as a marker for certain types of cancer, such as melanoma or breast cancer. It is also thought to be involved in the regulation of cellular processes that are relevant to many diseases, including heart disease and neurodegenerative diseases. This suggests that ARF5 may be a useful target for diagnostic tests and therapies that are designed to treat these diseases.

Overall, ARF5 is a complex protein that is involved in a variety of cellular processes. While much research has been done on its biology, there is still much to be learned about its role in the regulation of cell signaling pathways and its potential as a drug target or biomarker. Further studies are needed to fully understand the biology of ARF5 and its potential applications in medicine.

Protein Name: ADP Ribosylation Factor 5

Functions: GTP-binding protein involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus

The "ARF5 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about ARF5 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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