ARHGAP10: A Potential Drug Target for Cancer and Other Diseases

Target Name: ARHGAP10

NCBI ID: G79658

ARHGAP10

ARHGAP10: A Potential Drug Target for Cancer and Other Diseases

ARHGAP10 (Rho GTPase-activating protein 10) is a protein that plays a critical role in various cellular processes. It is a member of the Rho GTPase family, which is a well-known protein that plays a crucial role in cell signaling and cell- cell interaction. Unfortunately, ARHGAP10 has also been implicated in the development and progression of various diseases, including cancer. As a result, targeting this protein has become a promising strategy for the development of new treatments for these diseases. In this article, we will explore the biology of ARHGAP10 and its potential as a drug target or biomarker.

Biochemistry

ARHGAP10 is a 21 kDa protein that is expressed in various cell types, including neurons, astrocytes, and epithelial cells. It has a unique structure that consists of a catalytic active center and a 150 amino acid tail. The catalytic active center is composed of a Rossmann-fold, a key structural feature that binds GTPases. The 150 amino acid tail is involved in the regulation of ARHGAP10 function and is thought to play a role in its stability and interactions with other proteins.

Function

ARHGAP10 is a critical protein that is involved in various cellular processes. In addition to its role in cell signaling, ARHGAP10 is also involved in the regulation of cell-cell interaction and the development of various diseases.

ARHGAP10 plays a role in cell signaling by regulating the activity of several protein kinases, including PKA, PKC, and CRK. These enzymes are involved in various cellular processes, including cell signaling, cell-cell interaction, and inflammation. By regulating the activity of these enzymes, ARHGAP10 helps to maintain the balance of cellular signaling and ensure the integrity of cellular processes.

ARHGAP10 is also involved in the regulation of cell-cell interaction. It plays a role in the formation of tight junctions, which are a type of cell-cell barrier that helps to maintain the integrity of the intercellular space. In addition, ARHGAP10 is involved in the regulation of cell adhesion, which is the process by which cells stick together and form tissues.

ARHGAP10 is also involved in the development and progression of various diseases, including cancer. It has been shown to be involved in the regulation of several key signaling pathways that are involved in cancer development, including the G1/S transition, cell cycle progression, and angiogenesis. In addition, ARHGAP10 has been shown to play a role in the regulation of apoptosis, which is the process by which cells die when they have reached their lifespan.

Drug Targeting

Targeting ARHGAP10 is a promising strategy for the development of new treatments for various diseases. Several studies have shown that targeting ARHGAP10 with small molecules can result in the inhibition of its functions and the inhibition of the processes it is involved in.

One of the most promising strategies for targeting ARHGAP10 is the use of small molecules that inhibit the activity of GTPases. GTPases are involved in the regulation of various cellular processes, including cell signaling and cell-cell interaction. By inhibiting the activity of these enzymes, small molecules can reduce the amount of signaling that is occurring in the cell and potentially reduce the risk of cancer.

Another strategy for targeting ARHGAP10 is the use of small molecules that inhibit the formation of tight junctions. Tight junctions are a type of cell-cell barrier that helps to maintain the integrity of the intercellular space. By inhibiting

Protein Name: Rho GTPase Activating Protein 10

Functions: GTPase activator for the small GTPases RhoA and Cdc42 by converting them to an inactive GDP-bound state. Essential for PTKB2 regulation of cytoskeletal organization via Rho family GTPases. Inhibits PAK2 proteolytic fragment PAK-2p34 kinase activity and changes its localization from the nucleus to the perinuclear region. Stabilizes PAK-2p34 thereby increasing stimulation of cell death (By similarity)

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The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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