Understanding ARG2: Potential Drug Target Or Biomarker (G384)

Target Name: ARG2

NCBI ID: G384

ARG2

Understanding ARG2: Potential Drug Target Or Biomarker

ARG2 (Arginase II) is a protein that is expressed in the kidney, and it is involved in the regulation of the blood flow to the kidneys. It is a key enzyme in the arginine pathway, which is a critical pathway for the production of nitric oxide, a molecule that causes blood vessels to relax and widen, leading to increased blood flow to the body's tissues.

Research has suggested that ARG2 may be a drug target or biomarker for several conditions, including hypertension, heart failure, and diabetes. In hypertension, high blood pressure can damage the kidneys and increase the risk of kidney damage or failure. By blocking the activity of ARG2, researchers may be able to reduce the damage caused by high blood pressure and improve kidney function.

In heart failure, ARG2 has been shown to be involved in the regulation of the structure and function of the heart muscle. It has been shown to help protect the heart muscle from damage caused by stress, and it may also play a role in the treatment of heart failure.

In addition to its potential clinical applications, ARG2 has also been shown to be a potential biomarker for several diseases. For example, studies have suggested that ARG2 may be involved in the development and progression of cancer, and that its levels may be affected by a variety of cancer treatments.

Despite these promising findings, more research is needed to fully understand the role of ARG2 in the regulation of kidney function and the development and progression of disease.

In conclusion, ARG2 is a protein that is expressed in the kidney and is involved in the regulation of blood flow to the kidneys. It has been suggested as a potential drug target or biomarker for a variety of conditions, including hypertension, heart failure, and diabetes. Further research is needed to fully understand its role in the regulation of kidney function and the development and progression of disease.

Protein Name: Arginase 2

Functions: May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis. Extrahepatic arginase functions to regulate L-arginine bioavailability to nitric oxid synthase (NOS). Arginine metabolism is a critical regulator of innate and adaptive immune responses. Seems to be involved in negative regulation of the survival capacity of activated CD4(+) and CD8(+) T cells (PubMed:27745970). May suppress inflammation-related signaling in asthmatic airway epithelium (PubMed:27214549). May contribute to the immune evasion of H.pylori by restricting M1 macrophage activation and polyamine metabolism (By similarity). In fetal dendritic cells may play a role in promoting immune suppression and T cell TNF-alpha production during gestation (PubMed:28614294). Regulates RPS6KB1 signaling, which promotes endothelial cell senescence and inflammation and implicates NOS3/eNOS dysfunction (PubMed:22928666). Can inhibit endothelial autophagy independently of its enzymatic activity implicating mTORC2 signaling (PubMed:25484082). Involved in vascular smooth muscle cell senescence and apoptosis independently of its enzymatic activity (PubMed:23832324). Since NOS is found in the penile corpus cavernosum smooth muscle, the clitoral corpus cavernosum and the vagina, arginase-2 plays a role in both male and female sexual arousal (PubMed:12859189)

The "ARG2 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about ARG2 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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