MGAT1: Potential Drug Targets for Cancer and Other Diseases (G4245)

Target Name: MGAT1

NCBI ID: G4245

MGAT1

Other Name(s): MGAT1 variant 1 | GNT-1 | UDP-N-acetylglucosaminyl:alpha-3-D-mannoside beta-1,2-N-acetylglucosaminyltransferase I | GLYT1 | GlcNAc-T I | glcNAc-T I | MGAT1_HUMAN | GLCT1 | GLCNAC-TI | Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase, transcript variant 1 | splicing factor, arginine/serine-rich 19-like | alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase | Uridine diphosphoacetylglucosamine-alpha-1,3-mannosylglycoprotein beta-1,2-N-acetylglucosaminyltransferase | UDP-N-acetylglucosaminyl:alpha-1,3-D-mannoside-beta-1,2-N-acetylglucosaminyltransferase I | MGAT | Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase | N-acetylglucosaminyltransferase I | mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase | GNT-I | N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase I | Alpha-1,3-mannosyl-glycoprotein beta-1,2-N-acetylglucosaminyltransferase | GnTI

MGAT1: Potential Drug Targets for Cancer and Other Diseases

MGAT1 (Mesothelin-associated ganglioside Type 1) is a protein that is expressed in various tissues throughout the body, including the brain, pancreas, and gastrointestinal tract. It is a member of the ganglioside transmembrane protein (SMAP) family and is involved in the development and maintenance of the mesothelium, a thin layer of tissue that lines the inside of the body's cavities.

MGAT1 is also known as MGAT1 variant 1, and it has been identified as a potential drug target or biomarker for several diseases. In this article, we will explore the biology and significance of MGAT1, as well as its potential as a drug target.

MGAT1 is a transmembrane protein that is expressed in various tissues throughout the body, including the brain, pancreas, and gastrointestinal tract. It is a member of the ganglioside transmembrane protein (SMAP) family and is involved in the development and maintenance of the mesothelium, a thin layer of tissue that lines the inside of the body's cavities.

MGAT1 is highly expressed in the brain and is involved in the formation and maintenance of the blood-brain barrier (BBB). The BBB is a specialized barrier that separates the brain from the surrounding blood and is designed to protect the brain from harmful substances. MGAT1 is thought to play a key role in the formation and maintenance of the BBB by interacting with the protein transmembrane protease (TMP), which is a enzyme that is involved in the breakdown of tight junctions, which are a type of cell-cell barrier.

MGAT1 has also been shown to be involved in the development and maintenance of pancreatic cancer. pancreatic cancer is a particularly aggressive form of cancer that is highly lethal and has a poor prognosis. MGAT1 has been shown to be overexpressed in pancreatic cancer and may be a potential drug target or biomarker for this disease.

In addition to its role in the formation and maintenance of the BBB and pancreatic cancer, MGAT1 is also involved in the development and maintenance of other diseases. For example, MGAT1 has been shown to be involved in the development and maintenance of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease.

MGAT1 is also thought to be involved in the development and maintenance of certain types of cancer, such as colorectal cancer. Colorectal cancer is a particularly aggressive form of cancer that is common in the United States and has a poor prognosis. MGAT1 has been shown to be overexpressed in colorectal cancer and may be a potential drug target or biomarker for this disease.

In conclusion, MGAT1 is a protein that is involved in the development and maintenance of various diseases, including cancer. Its potential as a drug target or biomarker makes it an attractive target for researchers and clinicians who are working to develop new treatments for these diseases. Further research is needed to fully understand the role of MGAT1 in the development and maintenance of these diseases and to develop effective treatments.

Protein Name: Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase

Functions: Initiates complex N-linked carbohydrate formation. Essential for the conversion of high-mannose to hybrid and complex N-glycans

The "MGAT1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about MGAT1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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