MGAT4A: Key Enzyme in Glucosaminyl Transferase System (G11320)

Target Name: MGAT4A

NCBI ID: G11320

MGAT4A

Other Name(s): Mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isoenzyme A | mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isoenzyme A | Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A | alpha-1,3-mannosyl-glycoprotein beta-1,4-N-acetylglucosaminyltransferase | MGAT4A variant 1 | MGT4A_HUMAN | Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A (isoform 1) | GnT-IVa | GlcNAc-T IVa | UDP-N-acetylglucosamine: alpha-1,3-D-mannoside beta-1,4-N-acetylglucosaminyltransferase IVa | glcNAc-T IVa | GnT-4a | Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A, transcript variant 1 | mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A | GNT-IVA | N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase IVa | N-acetylglucosaminyltransferase IVa | Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A soluble form | UDP-N-acetylglucosamine:alpha1,3-d-mannoside beta1,4-N-acetylglucosaminyltransferase | UDP-GlcNAc:a-1,3-D-mannoside b-1,4-acetylglucosaminyltransferase IV | alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A | GNT-IV

MGAT4A: Key Enzyme in Glucosaminyl Transferase System

MGAT4A (Mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isoenzyme A) is a protein that is expressed in various tissues throughout the body. It is a key player in the glucosaminyl transferase system, which is responsible for the transfer of the amino acid glutamic acid to the N-acetylglucosamine molecule. This process is essential for the formation of the first link in the chain of glucose metabolism, which is a key step in the development of diabetes.

MGAT4A is an enzyme that is involved in the transfer of the N-acetylglucosamine molecule to the alpha-1,3-glucosaminyltransferase alpha-2,6-dimer. This alpha-2,6-dimer is then converted to the N-acetylglucosamine molecule and added to the N-acetylglucoside pathway. MGAT4A is a critical enzyme in this pathway, as it helps to regulate the conversion of the alpha-2,6-dimer to N-acetylglucosamine.

MGAT4A is also involved in the regulation of the levels of N-acetylglucosine in the brain, which is a key player in the regulation of the brain's energy metabolism. MGAT4A is also involved in the regulation of the levels of N-acetylglucoside in the liver, which is important for the detoxification of harmful substances in the body.

MGAT4A is a protein that has been identified as a potential drug target in the development of diabetes. Studies have shown that MGAT4A is expressed in the pancreas, which is the primary site of insulin production in the body. In addition, MGAT4A has been shown to be involved in the regulation of insulin sensitivity, which is an important factor in the development of type 2 diabetes.

MGAT4A is also involved in the regulation of the immune system, which is important for the fight against infection and disease. Studies have shown that MGAT4A is involved in the regulation of the production of immune cells in the body, which is important for the immune system's ability to fight off infections and diseases.

In addition to its role in the regulation of glucose and immune systems, MGAT4A is also involved in the regulation of the levels of various other molecules in the body. For example, MGAT4A is involved in the regulation of the levels of the amino acid lysine in the body, which is important for the maintenance of cellular health. MGAT4A is also involved in the regulation of the levels of the amino acid arginine in the body, which is important for the production of nitric oxide, a molecule that helps to relax blood vessels and improve blood flow.

MGAT4A is a protein that is expressed in various tissues throughout the body and plays a key role in the regulation of the glucosaminyl transferase system. It is a potential drug target in the development of diabetes and has also been shown to be involved in the regulation of various other molecules in the body. Further research is needed to fully understand the role of MGAT4A in the development of diabetes and its potential as a drug target.

Protein Name: Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A

Functions: Glycosyltransferase that catalyze the transfer of GlcNAc from UDP-GlcNAc to the GlcNAcbeta1-2Manalpha1-3 arm of the core structure of N-linked glycans through a beta1-4 linkage and participates in the production of tri- and tetra-antennary N-linked sugar chains (PubMed:17006639). Involved in glucose transport by mediating SLC2A2/GLUT2 glycosylation, thereby controlling cell-surface expression of SLC2A2 in pancreatic beta cells (By similarity)

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