The NFE2L1 Gene: A Potential Drug Target for Cancer and Inflammation

Target Name: NFE2L1

NCBI ID: G4779

NFE2L1

The NFE2L1 Gene: A Potential Drug Target for Cancer and Inflammation

The NFE2L1 gene, located on chromosome 1p36.1, plays a critical role in the regulation of nuclear factor (NF) 2 signaling pathway.NF2 is a transcription factor that regulates various cellular processes, including cell growth, differentiation, and inflammation. The NFE2L1 gene is a key regulator of the NF2 signaling pathway, and research into its function has led to the identification of potential drug targets and biomarkers.

The NFE2L1 gene is composed of a unique open-ended genomic region that contains multiple functional regions, including a Nfe3 motif, a LOCUS control region, and a TATA-like motif. The Nfe3 motif is a conserved protein-coding motif that is commonly found in transcription factors, and is involved in the formation of a nuclear complex that facilitates the interaction between the transcription factor and the DNA. The LOCUS control region is a critical region that regulates gene expression and is responsible for ensuring the stability of the NF2 complex. The TATA-like motif is a structural element that is commonly found in promoter regions of gene promoters and is involved in the regulation of gene expression.

The NFE2L1 gene is highly conserved across various species, and has been shown to be highly responsive to perturbations in gene expression levels. For example, studies have shown that changes in the NFE2L1 gene have been associated with various cellular processes, including cell growth, apoptosis, and inflammation. Additionally, the NFE2L1 gene has been shown to play a role in the regulation of cellular immortal cell states, and has been implicated in the development of various types of cancer.

The NFE2L1 gene has also been identified as a potential drug target due to its involvement in the regulation of cellular processes that are relevant to several types of cancer. For example, studies have shown that changes in the NFE2L1 gene have been associated with the development and progression of various types of cancer, including breast, ovarian, and colorectal cancers. Additionally, the NFE2L1 gene has been shown to play a role in the regulation of cell cycle progression, and is therefore thought to be a potential target for anti-cancer drugs that target the cell cycle.

The NFE2L1 gene has also been shown to play a role in the regulation of cellular inflammation, and is therefore a potential target for drugs that target inflammation. Studies have shown that changes in the NFE2L1 gene have been associated with the development of various types of inflammation, including inflammatory bowel disease and autoimmune diseases. Additionally, the NFE2L1 gene has been shown to play a role in the regulation of immune cell function, and is therefore thought to be a potential target for drugs that target immune system function.

In conclusion, the NFE2L1 gene is a unique and conserved genomic region that plays a critical role in the regulation of nuclear factor (NF) 2 signaling pathway. The NFE2L1 gene has been shown to be involved in a variety of cellular processes, including cell growth, apoptosis, and inflammation. Additionally, the NFE2L1 gene has been identified as a potential drug target due to its involvement in the regulation of cellular processes that are relevant to several types of cancer. Further research is needed to fully understand the function of the NFE2L1 gene and its potential as a drug target.

Protein Name: NFE2 Like BZIP Transcription Factor 1

Functions: Endoplasmic reticulum membrane sensor that translocates into the nucleus in response to various stresses to act as a transcription factor (PubMed:20932482, PubMed:24448410). Constitutes a precursor of the transcription factor NRF1 (By similarity). Able to detect various cellular stresses, such as cholesterol excess, oxidative stress or proteasome inhibition (PubMed:20932482). In response to stress, it is released from the endoplasmic reticulum membrane following cleavage by the protease DDI2 and translocates into the nucleus to form the transcription factor NRF1 (By similarity). Acts as a key sensor of cholesterol excess: in excess cholesterol conditions, the endoplasmic reticulum membrane form of the protein directly binds cholesterol via its CRAC motif, preventing cleavage and release of the transcription factor NRF1, thereby allowing expression of genes promoting cholesterol removal, such as CD36 (By similarity). Involved in proteasome homeostasis: in response to proteasome inhibition, it is released from the endoplasmic reticulum membrane, translocates to the nucleus and activates expression of genes encoding proteasome subunits (PubMed:20932482)

The "NFE2L1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about NFE2L1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets