NF-kappa-B: Regulating Inflammation and Pain Perception (G4798)

Target Name: NFRKB

NCBI ID: G4798

NFRKB

NF-kappa-B: Regulating Inflammation and Pain Perception

Nuclear factor-related to kappa-B-binding protein (NF-kappa-B) is a protein that plays a crucial role in cellular signaling. It is a protein that is highly expressed in various tissues and cells, including the brain, and is involved in various physiological processes, including inflammation, cell growth, and differentiation.

One of the functions of NF-kappa-B is to regulate the activity of other proteins that are involved in signaling pathways. These proteins include nuclear factor-related to p21 (NF-p21), which is a transcription factor that is involved in the regulation of cell growth and apoptosis. Another protein that is highly expressed in NF-kappa-B-positive cells is the transcription factor-related to DNA binding protein, called p65.

NF-kappa-B is also involved in the regulation of inflammation. It is a well-known fact that NF-kappa-B is involved in the regulation of various types of inflammation, including both acute and chronic inflammation. the production of pro-inflammatory cytokines, such as TNF-alpha, IL-1, and IL-6.

One of the ways that NF-kappa-B is involved in inflammation is through its ability to activate the transcription factor-related to gene expression (NF-GRE), which is a protein that is involved in the regulation of gene expression. NF-GRE is able to bind to specific DNA sequences and regulate the activity of the transcription factors that are involved in gene expression. This is important because NF-GRE is able to control the production of pro-inflammatory cytokines, which can contribute to the development of various types of inflammation.

Another way that NF-kappa-B is involved in inflammation is through its role in the regulation of pain perception. NF-kappa-B is involved in the production of pro-inflammatory cytokines, such as TNF-alpha, which is known to contribute to pain perception. Additionally, NF-kappa-B is also involved in the regulation of the production of neurotransmitters, such as serotonin and dopamine, which can also contribute to pain perception.

In conclusion, NF-kappa-B is a protein that is involved in a variety of cellular processes, including inflammation, cell growth, and differentiation. Its role in these processes makes it an attractive target for drug development. The use of small molecules, such as inhibitors of NF-GRE, have been shown to be effective in reducing inflammation and the symptoms associated with pain perception. Further research is needed to fully understand the role of NF-kappa-B in cellular processes and to develop effective treatments.

Protein Name: Nuclear Factor Related To KappaB Binding Protein

Functions: Binds to the DNA consensus sequence 5'-GGGGAATCTCC-3'

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