NFS1: A Potential Drug Target for Various Diseases (G9054)

Target Name: NFS1

NCBI ID: G9054

NFS1

NFS1: A Potential Drug Target for Various Diseases

NFS1 (N-Fucsinyl-L-Cysteine Desulfurase) is a protein that is expressed in various tissues throughout the body, including the brain, heart, lungs, and liver. It is a key enzyme in the detoxification process of cysteine, a sulfur-containing amino acid that is important for the structure and function of many proteins in the body. NFS1 is also involved in the metabolism of other molecules, including glucose and lipids.

The research on NFS1 has suggested that it may have a variety of potential functions, including modulating the levels of inflammation and oxidative stress in the body. It has also been shown to be involved in the development and progression of certain diseases, such as cancer and neurodegenerative disorders.

One of the most promising aspects of NFS1 research is its potential as a drug target. The ability of NFS1 to participate in the detoxification of cysteine, as well as its involvement in the metabolism of other molecules, has led to the possibility that it may be a useful target for the treatment of certain diseases.

One potential mechanism by which NFS1 may be involved in the development and progression of cancer is its role in modulating the levels of reactive oxygen species (ROS) in the body. ROS are free radicals that can damage cellular components and contribute to the development of certain diseases, including cancer. NFS1 has been shown to help regulate the production of ROS, which may be a potential target for the development of cancer therapies.

Another potential mechanism by which NFS1 may be involved in the development and progression of neurodegenerative disorders is its role in the metabolism of cysteine. Cysteine is a sulfur-containing amino acid that is involved in the structure and function of many proteins in the brain, including those involved in the development and maintenance of neural connections. NFS1 has been shown to play a key role in the metabolism of cysteine, which may be a potential target for the treatment of neurodegenerative disorders.

In addition to its potential role in the detoxification of cysteine and its involvement in the metabolism of other molecules, NFS1 has also been shown to be involved in the development and progression of certain diseases. For example, NFS1 has been shown to be involved in the development of neurodegenerative disorders, such as Alzheimer's disease and Parkinson's disease. It has also been shown to be involved in the development of certain cancers, such as breast and colorectal cancers.

Given the potential involvement of NFS1 in the development and progression of a variety of diseases, it is an attractive target for drug development. Studies are currently being conducted to determine the full extent of NFS1's involvement in these processes, as well as its potential efficacy as a drug.

In conclusion, NFS1 is a protein that is expressed in various tissues throughout the body and is involved in the detoxification process of cysteine as well as the metabolism of other molecules. The research on NFS1 has suggested that it may have a variety of potential functions, including modulating the levels of inflammation and oxidative stress in the body and being involved in the development and progression of certain diseases. Given its involvement in these processes, NFS1 is an attractive target for drug development and has the potential to be a valuable tool in the treatment of a variety of diseases.

Protein Name: NFS1 Cysteine Desulfurase

Functions: Cysteine desulfurase, of the core iron-sulfur cluster (ISC) assembly complex, that catalyzes the desulfuration of L-cysteine to L-alanine, as component of the cysteine desulfurase complex, leading to the formation of a cysteine persulfide intermediate at the active site cysteine residue and participates in the [2Fe-2S] clusters assembly on the scaffolding protein ISCU (PubMed:29097656, PubMed:31101807, PubMed:18650437). The persulfide is then transferred on the flexible Cys loop from the catalytic site of NFS1 to the surface of NFS1 (PubMed:29097656). After the NFS1-linked persulfide sulfur is transferred to one of the conserved Cys residues of the scaffold, a reaction assisted by FXN (By similarity). The core iron-sulfur cluster (ISC) assembly complex is involved in the de novo synthesis of a [2Fe-2S] cluster, the first step of the mitochondrial iron-sulfur protein biogenesis. This process is initiated by the cysteine desulfurase complex (NFS1:LYRM4:NDUFAB1) that produces persulfide which is delivered on the scaffold protein ISCU in a FXN-dependent manner. Then this complex is stabilized by FDX2 which provides reducing equivalents to accomplish the [2Fe-2S] cluster assembly. Finally, the [2Fe-2S] cluster is transferred from ISCU to chaperone proteins, including HSCB, HSPA9 and GLRX5 (By similarity)

The "NFS1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about NFS1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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