ORC1: A Protein Involved in DNA Replication and Disease (G4998)

Target Name: ORC1

NCBI ID: G4998

ORC1

ORC1: A Protein Involved in DNA Replication and Disease

ORC1 (Replication control protein 1) is a protein that plays a crucial role in the regulation of DNA replication in eukaryotic cells. ORC1 is a single-domain protein that contains a unique nucleotide-binding oligomerization domain (NBO), which is responsible for binding to single-stranded DNA and preventing its from being replicated.

ORC1 is expressed in most eukaryotic cells and is highly conserved across different species. It is found in a variety of cellular organelles, including the nucleus, mitochondria, and endoplasmic reticulum. ORC1 is also involved in the regulation of gene expression, and has been shown to play a role in the development and progression of various diseases.

One of the unique features of ORC1 is its ability to interact with specific DNA sequences. ORC1 can bind to single-stranded DNA with high affinity, and its NBO domain is specifically designed to interact with G-Crich sequences. This interaction between ORC1 and DNA allows it to prevent DNA from being replicated when a G-Crich template is present.

ORC1 has been shown to play a role in a variety of diseases, including cancer, neurodegenerative diseases, and developmental disorders. In cancer, ORC1 has been shown to promote the growth and survival of cancer cells by preventing DNA replication and inhibiting the apoptosis that occurs when DNA is replicated. In neurodegenerative diseases, ORC1 has been shown to contribute to the progression of neurodegeneration by preventing the production of new neurons and misregulating the production of neurotransmitters. In developmental disorders, ORC1 has been shown to play a role in the development of genetic disorders by preventing the proper formation of tissues and organs.

Due to its involvement in so many different cellular processes, ORC1 has been identified as a potential drug target and biomarker. Researchers have been studying the potential therapeutic benefits of targeting ORC1, with the goal of using it to treat a variety of diseases. One approach to targeting ORC1 is to use small molecules to inhibit its activity, either by binding to its NBO domain or by inhibiting its ability to interact with DNA.

In addition to its potential as a drug, ORC1 is also a promising biomarker for a variety of diseases. Its ability to interact with specific DNA sequences makes it a useful tool for the detection and quantification of DNA replication in different organisms. ORC1 has also been shown to be expressed in a variety of tissues and cells, which makes it a potential target for diagnostic tests.

Overall, ORC1 is a protein that plays a crucial role in the regulation of DNA replication in eukaryotic cells. Its unique NBO domain and ability to interact with specific DNA sequences make it a potential drug target and biomarker. Further research is needed to fully understand the role of ORC1 in different cellular processes and to develop effective treatments for diseases associated with its dysfunction.

Protein Name: Origin Recognition Complex Subunit 1

Functions: Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication

The "ORC1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about ORC1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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