HTRA3: A Potential Drug Target and Biomarker (G94031)

Target Name: HTRA3

NCBI ID: G94031

HTRA3

HTRA3: A Potential Drug Target and Biomarker

Heat-threshold requirement factor A3 (HTRA3) is a non-coding RNA molecule that has been identified as a potential drug target and biomarker in various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. HTRA3 plays a crucial role in the regulation of thermal stress responses in cells and is involved in a wide range of physiological processes, including DNA damage repair, cell apoptosis, and inflammation.

In recent years, researchers have made significant progress in understanding the functions of HTRA3. Several studies have shown that HTRA3 is involved in various cellular processes, including cell growth, differentiation, and stress responses. Additionally, several studies have identified potential binding sites in the HTRA3 gene and have demonstrated its involvement in various signaling pathways, including TGF-β, NF-kappa-B, and AP-1.

HTRA3 has also been shown to be involved in the development and progression of various diseases, including cancer. For example, studies have shown that HTRA3 is overexpressed in various types of cancer and that its levels are associated with poor prognosis. Additionally, HTRA3 has been shown to promote the growth and survival of cancer cells, making it a potential drug target.

In addition to its potential as a drug target, HTRA3 has also been identified as a potential biomarker. Several studies have shown that HTRA3 is expressed in various tissues and that its levels are associated with various diseases, including cancer. Additionally, HTRA3 has been shown to be a good candidate for diagnostic biomarker for various diseases, including neurodegenerative diseases and autoimmune disorders.

In conclusion, HTRA3 is a non-coding RNA molecule that has been identified as a potential drug target and biomarker in various diseases. Further research is needed to fully understand its functions and to develop effective treatments for these diseases.

Protein Name: HtrA Serine Peptidase 3

Functions: Serine protease that cleaves beta-casein/CSN2 as well as several extracellular matrix (ECM) proteoglycans such as decorin/DCN, biglycan/BGN and fibronectin/FN1. Inhibits signaling mediated by TGF-beta family proteins possibly indirectly by degradation of these ECM proteoglycans (By similarity). May act as a tumor suppressor. Negatively regulates, in vitro, trophoblast invasion during placental development and may be involved in the development of the placenta in vivo. May also have a role in ovarian development, granulosa cell differentiation and luteinization (PubMed:21321049, PubMed:22229724)

The "HTRA3 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about HTRA3 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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