HTR3D: A Potential Drug Target and Biomarker for Psychiatric Disorders

Target Name: HTR3D

NCBI ID: G200909

HTR3D

HTR3D: A Potential Drug Target and Biomarker for Psychiatric Disorders

Human tryptophan hydroxylase (HTR3D) is a enzyme involved in the synthesis of neurotransmitters, including serotonin and dopamine, which are responsible for regulating various physiological processes in the brain. The HTR3D gene has been identified as a potential drug target or biomarker for various psychiatric and neurological disorders. In this article, we will discuss the HTR3D protein, its function, potential drug targets, and its potential as a biomarker for certain diseases.

Function of HTR3D

HTR3D is a member of the tryptophan hydroxylase family, which includes four structurally similar subunits: HTR1A, HTR1B, HTR2A, and HTR2B. HTR3D is a 144 amino acid protein that has a calculated pI of 9.6 and a calculated molecular weight of 17.9 kDa. It is expressed in various tissues and cells, including brain, heart, and pancreas, and is involved in the synthesis of tryptophan, which is a key precursor of neurotransmitters, such as serotonin and dopamine.

Potential Drug Targets

HTR3D has been identified as a potential drug target due to its involvement in the synthesis of neurotransmitters. The synthesis of tryptophan is a critical step in the production of these neurotransmitters, and disruptions in this process can lead to various psychiatric and neurological disorders. For example, individuals with the HTR3D gene mutation have been reported to have symptoms of psychosis, including auditory hallucinations and delusions, which may be attributed to disruptions in the production of tryptophan.

In addition to its involvement in neurotransmitter synthesis, HTR3D has also been shown to play a role in inflammation and pain signaling. For instance, HTR3D has been shown to be involved in the production of pro-inflammatory cytokines, such as IL-1尾, which may contribute to the development of inflammatory diseases.

HTR3D has also been shown to be involved in the regulation of cell survival and proliferation. For example, studies have shown that HTR3D can induce cell death in various cell types, including cancer cells, which may be a potential mechanism for its use as a cancer therapeutic.

Potential Biomarker

HTR3D has also been shown to be a potential biomarker for various psychiatric and neurological disorders. For example, individuals with the HTR3D gene mutation have been reported to have symptoms of psychosis, including auditory hallucinations and delusions, which may be attributed to disruptions in the production of tryptophan. Additionally, HTR3D has been shown to be involved in the production of pro-inflammatory cytokines, which may contribute to the development of inflammatory diseases.

In conclusion, HTR3D is a protein that is involved in the synthesis of neurotransmitters and has been identified as a potential drug target for various psychiatric and neurological disorders. Its potential as a biomarker for various diseases makes it an attractive target for future research and development.

Protein Name: 5-hydroxytryptamine Receptor 3D

Functions: This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses. It is a cation-specific, but otherwise relatively nonselective, ion channel

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•   general information;
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•   expression level;
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The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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