ANAPC11: Key Subunit of The ANAPC Protein Complex (G51529)

Target Name: ANAPC11

NCBI ID: G51529

ANAPC11

ANAPC11: Key Subunit of The ANAPC Protein Complex

The ANAPC11 protein is a member of the Anaphase-promoting complex (APC), a protein complex that plays a critical role in the process of DNA replication in eukaryotic cells. The APC is composed of several subunits, including ANAPC11, which is a key subunit that promotes the initiation of anaphase, the stage of DNA replication where the double helix is 鈥嬧?媟eplicated in opposite directions.

ANAPC11 is a 21-kDa protein that is expressed in a variety of tissues and cells, including muscle, liver, and brain. It is composed of a unique fusion of several distinct protein domains, including a nucleotide-binding domain (NBD), a transmembrane domain (TMD), and a cytoplasmic domain (CPD). The NBD and TMD domains give ANAPC11 its unique structure and function, as they are responsible for the protein's ability to interact with DNA and form a complex with the APC.

One of the key functions of ANAPC11 is its ability to promote the initiation of anaphase. During DNA replication, ANAPC11 forms a complex with the APC to form the Anaphase-promoting complex (APC) subunit 11 (ANAPC11-SP1). This complex plays a critical role in the initiation of anaphase, as ANAPC11 is able to physically interact with the APC to promote the formation of the complex.

ANAPC11 has also been shown to play a role in the regulation of gene expression. Studies have shown that ANAPC11 can physically interact with the APC subunit 12 (ANAPC12), which is a negative regulator of the transcription factor TATA-repeat enhancer (TRE) . This interaction between ANAPC11 and ANAPC12 suggests that ANAPC11 may be a potential drug target for the regulation of gene expression.

In addition to its role in promoting anaphase and regulating gene expression, ANAPC11 has also been shown to play a role in the regulation of DNA replication itself. Studies have shown that ANAPC11 can physically interact with the APC subunit 2 (ANAPC2), which is a critical subunit for the regulation of DNA replication. This interaction between ANAPC11 and ANAPC2 suggests that ANAPC11 may be a potential biomarker for the regulation of DNA replication, and that it may be a useful target for drug development.

Overall, ANAPC11 is a complex protein that plays a critical role in the regulation of DNA replication in eukaryotic cells. Its unique structure and function, as well as its ability to promote the initiation of anaphase and regulate gene expression, make ANAPC11 an attractive target for drug development. Further research is needed to fully understand the mechanisms of ANAPC11's function and its potential as a drug target.

Protein Name: Anaphase Promoting Complex Subunit 11

Functions: Together with the cullin protein ANAPC2, constitutes the catalytic component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. May recruit the E2 ubiquitin-conjugating enzymes to the complex

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