ATP7A: A Potential Drug Target and Biomarker (G538)

Target Name: ATP7A

NCBI ID: G538

ATP7A

ATP7A: A Potential Drug Target and Biomarker

ATP (adenosine triphosphate) is a crucial molecule in the cell's energy metabolism. It is a small molecule that plays a vital role in the transfer of energy from the cell's energy sources to its activities. ATP is synthesized from adenosine and phosphate groups, and it is essential for maintaining the cell's physiological functions, including muscle contractions, blood clotting, and cell signaling.

Recently, researchers have discovered that ATP7A, a gene encoding for a protein involved in the replication of DNA, has the potential to be a drug target and biomarker for various diseases. The discovery of ATP7A's involvement in gene replication has important implications for the development of new treatments for human diseases.

ATP7A's Role in DNA Replication

ATP7A is a key gene in the replication of DNA in the cell's nucleus. It encodes a protein called DNA-binding protein (DNBP), which is essential for the proper functioning of DNA replication. DNA-binding proteins are known to play a crucial role in regulating gene expression, and they are involved in the development and progression of various diseases.

ATP7A's Role in Cancer

The rapid and uncontrolled growth of cancer cells is a major contributor to human disease. Cancer cells have the ability to replicate their DNA at an unprecedented rate, which allows them to evade the immune system and continue to grow uncontrollably.

Research has shown that DNBP, the protein encoded by ATP7A, is involved in the regulation of DNA replication in cancer cells. In fact, high levels of DNBP have been observed in various types of cancer, including breast, lung, and ovarian cancer.

The potential implications of these findings are that targeting ATP7A with drugs or other therapeutic agents may be an effective way to inhibit the growth of cancer cells and potentially lead to a more effective treatment for cancer.

ATP7A as a Biomarker

ATP7A is also a potential biomarker for various diseases. Its involvement in DNA replication makes it an attractive target for therapies that aim to disrupt the replication of cancer cells. By inhibiting ATP7A's function, therapies may be able to reduce the growth of cancer cells and potentially lead to a more effective treatment for cancer.

In addition, ATP7A may also be used as a biomarker to monitor the effectiveness of certain therapies. For example, the level of ATP7A in cancer cells can be used to determine the effectiveness of a particular drug or treatment. This could be an important tool in the development of new cancer therapies, as it allows researchers to better understand the mechanisms of these therapies and determine their effectiveness in humans.

Conclusion

In conclusion, the discovery of ATP7A's involvement in the replication of DNA and its potential as a drug target and biomarker for various diseases has significant implications for the development of new treatments for human disease. Further research is needed to fully understand the role of ATP7A in disease and to explore its potential as a therapeutic agent.

Protein Name: ATPase Copper Transporting Alpha

Functions: ATP-driven copper (Cu(+)) ion pump that plays an important role in intracellular copper ion homeostasis (PubMed:10419525, PubMed:11092760, PubMed:28389643). Within a catalytic cycle, acquires Cu(+) ion from donor protein on the cytoplasmic side of the membrane and delivers it to acceptor protein on the lumenal side. The transfer of Cu(+) ion across the membrane is coupled to ATP hydrolysis and is associated with a transient phosphorylation that shifts the pump conformation from inward-facing to outward-facing state (PubMed:10419525, PubMed:19453293, PubMed:19917612, PubMed:31283225, PubMed:28389643). Under physiological conditions, at low cytosolic copper concentration, it is localized at the trans-Golgi network (TGN) where it transfers Cu(+) ions to cuproenzymes of the secretory pathway (PubMed:28389643, PubMed:11092760). Upon elevated cytosolic copper concentrations, it relocalizes to the plasma membrane where it is responsible for the export of excess Cu(+) ions (PubMed:10419525, PubMed:28389643). May play a dual role in neuron function and survival by regulating cooper efflux and neuronal transmission at the synapse as well as by supplying Cu(+) ions to enzymes such as PAM, TYR and SOD3 (PubMed:28389643) (By similarity). In the melanosomes of pigmented cells, provides copper cofactor to TYR to form an active TYR holoenzyme for melanin biosynthesis (By similarity)

The "ATP7A Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about ATP7A comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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