PUS7: A Drug Target / Disease Biomarker (G54517)

Target Name: PUS7

NCBI ID: G54517

PUS7

PUS7: A Drug Target / Disease Biomarker

PUS7, also known as Pus7, is a protein that is expressed in the skin and other tissues of many organisms, including humans. It is a member of the Pusvela domain family and is characterized by the presence of a single transmembrane region and a cytoplasmic tail.

PUS7 has been identified as a potential drug target and has been shown to play a role in a variety of biological processes, including cell signaling, inflammation, and tissue repair. Its unique structure and expression patterns have also led to a focus on its potential as a biomarker for disease diagnosis and monitoring.

One of the key functions of PUS7 is its role in cell signaling. PUS7 is a known receptor for several different signaling pathways, including the TGF-β pathway and the Wnt pathway. This suggests that it plays a role in the regulation of cell growth, differentiation, and survival.

In addition to its role in cell signaling, PUS7 is also involved in the regulation of inflammation. Its expression has been shown to be elevated in a variety of inflammatory diseases, including cancer, neuroinflammatory diseases, and autoimmune disorders. This suggests that it may play a role in the regulation of inflammation and the potential development of these diseases.

PUS7's role in tissue repair is also an interesting aspect of its biology. Its expression has been shown to be elevated in a variety of tissues after injury or disease, including the skin, muscle, and nervous system. This suggests that it may play a role in the regulation of tissue repair and regeneration.

Despite its potential as a drug target and biomarker, much more research is needed about the specific functions of PUS7 in these biological processes. Understanding the full scope of its functions will be important for the development of new treatments and therapies for a variety of diseases.

In conclusion, PUS7 is a protein that is expressed in a variety of tissues and has been shown to play a role in several important biological processes, including cell signaling, inflammation, and tissue repair. Its unique structure and expression patterns make it an attractive target for further research and potential development of new treatments. Further studies are needed to fully understand its functions and potential as a drug and biomarker.

Protein Name: Pseudouridine Synthase 7

Functions: Pseudouridylate synthase that catalyzes pseudouridylation of RNAs (PubMed:28073919, PubMed:29628141, PubMed:30778726, PubMed:31477916, PubMed:35051350, PubMed:34718722). Acts as a regulator of protein synthesis in embryonic stem cells by mediating pseudouridylation of RNA fragments derived from tRNAs (tRFs): pseudouridylated tRFs inhibit translation by targeting the translation initiation complex (PubMed:29628141). Also catalyzes pseudouridylation of mRNAs: mediates pseudouridylation of mRNAs with the consensus sequence 5'-UGUAG-3' (PubMed:28073919, PubMed:31477916, PubMed:35051350). Acts as a regulator of pre-mRNA splicing by mediating pseudouridylation of pre-mRNAs at locations associated with alternatively spliced regions (PubMed:35051350). Pseudouridylation of pre-mRNAs near splice sites directly regulates mRNA splicing and mRNA 3'-end processing (PubMed:35051350). In addition to mRNAs and tRNAs, binds other types of RNAs, such as snRNAs, Y RNAs and vault RNAs, suggesting that it can catalyze pseudouridylation of many RNA types (PubMed:29628141)

The "PUS7 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about PUS7 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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