Overview of Nectin-like 5 (Nl5): Structure, Function and Potential Drug Targets

Target Name: PVR

NCBI ID: G5817

Content of Review Report on PVR Target / Biomarker

PVR

Overview of Nectin-like 5 (Nl5): Structure, Function and Potential Drug Targets

Nectin-like 5 (Nl5) is a protein that is expressed in various cell types of the human body. Nl5 is a member of the nucleotide-binding oligomerization domain (NOD) family, which is a group of proteins that play a critical role in regulating DNA replication, transcription, and repair. Nl5 is highly expressed in various tissues of the human body, including the brain, heart, liver, and pancreas.

Purpose of the Article

The purpose of this article is to provide an overview of Nl5, including its structure, function, and potential as a drug target or biomarker. Nl5 is a protein that is involved in various cellular processes, including cell signaling, DNA replication, and repair, making it an attractive target for drug development.

Structure and Function

Nl5 is a 21-kDa protein that is composed of 219 amino acid residues. Nl5 has a nucleotide-binding oligomerization domain (NOD), which is responsible for its DNA-binding properties. The NOD is composed of a nucleotide-binding domain and a carboxylic acid-containing domain. The NOD plays a critical role in regulating DNA replication and transcription by interacting with various DNA-binding proteins.

Nl5 is involved in various cellular processes, including cell signaling, DNA replication, and repair. In cell signaling, Nl5 is involved in the regulation of cell cycle progression, apoptosis, and neurodegeneration. Nl5 is also involved in DNA replication and repair, which are critical processes for maintaining cellular genetic diversity and integrity.

In addition to its role in cell signaling and DNA replication and repair, Nl5 has also been shown to have potential as a drug target. Nl5 has been shown to interact with various signaling proteins, including T-cell signaling pathway proteins. This suggests that Nl5 may be a target for drugs that are effective in treating T-cell-related diseases, such as cancer.

Potential as a Biomarker

Nl5 has also been shown to have potential as a biomarker for various diseases. For example, Nl5 has been shown to be highly expressed in pancreatic cancer, and may be a useful biomarker for this disease. Additionally, Nl5 has been shown to be involved in the regulation of cellular processes, which may make it a useful biomarker for certain types of neurodegenerative diseases.

Drug Targets

Nl5 has been identified as a potential drug target due to its involvement in various cellular processes that are involved in disease. One of the primary drug targets for Nl5 is the T-cell signaling pathway. This pathway is involved in the regulation of immune function, and is a critical target for the development of cancer therapies.

Another potential drug target for Nl5 is the regulation of cell cycle progression. This pathway is involved in the regulation of cellular growth and division, and is a critical target for the development of therapies for various types of cancer. Nl5 has been shown to be involved in the regulation of cell cycle progression, which may make it a potential target for therapies that are effective in treating cancer.

Conclusion

Nectin-like 5 (Nl5) is a protein that is involved in various cellular processes that are critical for maintaining cellular health and function. Nl5 has been shown to have potential as a drug target due to its involvement in the T-cell signaling pathway and the regulation of cell cycle progression. Further research is needed to fully understand the role of Nl5 in disease and to develop effective therapies that target Nl5.

Protein Name: PVR Cell Adhesion Molecule

Functions: Mediates NK cell adhesion and triggers NK cell effector functions. Binds two different NK cell receptors: CD96 and CD226. These interactions accumulates at the cell-cell contact site, leading to the formation of a mature immunological synapse between NK cell and target cell. This may trigger adhesion and secretion of lytic granules and IFN-gamma and activate cytotoxicity of activated NK cells. May also promote NK cell-target cell modular exchange, and PVR transfer to the NK cell. This transfer is more important in some tumor cells expressing a lot of PVR, and may trigger fratricide NK cell activation, providing tumors with a mechanism of immunoevasion. Plays a role in mediating tumor cell invasion and migration

The "PVR Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about PVR comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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