PPM1A: A Potential Drug Target and Biomarker for Protein Phosphatase 1A (ISO Form 3)

Target Name: PPM1A

NCBI ID: G5494

PPM1A

PPM1A: A Potential Drug Target and Biomarker for Protein Phosphatase 1A (ISO Form 3)

Protein phosphatase 1A (ISO Form 3) is an essential enzyme involved in various cellular processes, including cell signaling, DNA replication, and metabolism. The regulation of protein phosphatase 1A activity is critical for maintaining cellular homeostasis and has been implicated in numerous diseases, including cancer, neurodegenerative diseases, and metabolic disorders. As a result, targeting protein phosphatase 1A has become an attractive research topic in recent years.

In this article, we will discuss protein phosphatase 1A (ISO Form 3), its functions, potential drug targets, and role as a biomarker. We will explore the current understanding of protein phosphatase 1A biology and highlight its potential as a drug target and biomarker.

Current Understanding of Protein Phosphatase 1A (ISO Form 3)

Protein phosphatase 1A (ISO Form 3) is a 26kDa protein that is highly conserved across various species, including humans. It is a critical enzyme involved in the regulation of protein targets, including several essential cellular processes. The activity of protein phosphatase 1A can be regulated by various factors, including calcium ions, reactive oxygen species (ROS), and protein kinases.

In addition to its role in cellular signaling, protein phosphatase 1A is also involved in maintaining DNA replication and metabolism. It has been shown to play a crucial role in regulating the replication of DNA in various cell types, including cancer cells. Furthermore, the activity of protein phosphatase 1A has also been implicated in metabolism, specifically in the regulation of lipid metabolism.

Potential Drug Targets

The regulation of protein phosphatase 1A activity is a attractive target for drug development due to its involvement in various cellular processes that are associated with various diseases. Several potential drug targets have been identified for protein phosphatase 1A, including:

1. Ca2+ signaling pathway: Activation of protein phosphatase 1A by calcium ions leads to its activity, which can contribute to the regulation of various cellular processes, including muscle contraction, neural transmission, and inflammation. Therefore, inhibition of protein phosphatase 1A activity by small molecules or antibodies targeting calcium ions could be a potential drug target for various diseases, including cancer and neurodegenerative diseases.
2. Oxidative stress: Chronic oxidative stress has been linked to the development of various diseases, including cancer and neurodegenerative diseases. Protein phosphatase 1A has been shown to regulate oxidative stress responses in cells, including the regulation of reactive oxygen species (ROS). Therefore, targeting protein phosphatase 1A activity by small molecules or antibodies that inhibit its function could be a potential drug target for diseases associated with oxidative stress, such as cancer and neurodegenerative diseases.
3. Metabolism: The regulation of lipid metabolism is a key aspect of cellular biology, and protein phosphatase 1A is involved in this process. It has been shown to play a crucial role in the regulation of lipid metabolism, including the regulation of lipid uptake and storage in the endoplasmic reticulum (ER) and the regulation of lipid breakdown. Therefore, targeting protein phosphatase 1A activity by small molecules or antibodies that inhibit its function could be a potential drug target for diseases associated with altered lipid metabolism, such as metabolic disorders.

Biomarkers

The regulation of protein phosphatase 1A (ISO Form 3) activity is a critical process that is involved in various cellular processes. Therefore, the measurement of protein phosphatase 1A activity is a useful biomarker for the diagnosis and

Protein Name: Protein Phosphatase, Mg2+/Mn2+ Dependent 1A

Functions: Enzyme with a broad specificity. Negatively regulates TGF-beta signaling through dephosphorylating SMAD2 and SMAD3, resulting in their dissociation from SMAD4, nuclear export of the SMADs and termination of the TGF-beta-mediated signaling. Dephosphorylates PRKAA1 and PRKAA2. Plays an important role in the termination of TNF-alpha-mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB

The "PPM1A Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about PPM1A comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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