PPIAP46: A Potential Drug Target and Biomarker for Peptidyl Prolyl Isomerase A

Target Name: PPIAP46

NCBI ID: G729739

PPIAP46

Other Name(s): peptidylprolyl isomerase A pseudogene 46 | Peptidylprolyl isomerase A pseudogene 46

PPIAP46: A Potential Drug Target and Biomarker for Peptidyl Prolyl Isomerase A

Peptidyl prolyl isomerase A (PPIAP46) is an essential enzyme that plays a crucial role in the regulation of protein stability and dynamics. It is a member of the superfamily of prolyl isomerases and is responsible for the conversion of proline to its isopolylproline equivalent, which is then hydrolyzed by other enzymes to release the polyproline side chain. PPIAP46 is highly conserved across various species, including humans, and its function in various cellular processes is well understood.

Despite its importance, PPIAP46 has remained a relatively unexplored target for researchers. This lack of understanding may change soon, as several studies have identified PPIAP46 as a potential drug target and biomarker. In this article, we will explore the current state of research on PPIAP46 and its potential as a drug target and biomarker.

Expression and Localization of PPIAP46

PPIAP46 is a cytoplasmic protein that is primarily expressed in the endoplasmic reticulum (ER) and cytoplasm. It is also found in various cellular organelles, including the mitochondria, endoplasmic reticulum, and cytosol. PPIAP46 is primarily localized to the cytoplasm, where it is involved in the delivery and processing of its target, polyproline.

Expression of PPIAP46 is regulated by various factors, including its own protein levels, the levels of its precursor protein, and the levels of its downstream targets. Studies have shown that PPIAP46 levels can be regulated by factors such as cytokines, growth factors, and cellular stressors.

In addition to its cytoplasmic localization, PPIAP46 has also been shown to be present in various cellular organelles, including the endoplasmic reticulum and the cytosol. This suggests that PPIAP46 plays a role in the delivery and processing of its target, polyproline, both in the cytoplasm and in the ER.

Function and Interaction of PPIAP46

PPIAP46 is a highly conserved protein that is involved in the regulation of protein stability and dynamics. It is a member of the superfamily of prolyl isomerases and is responsible for the conversion of proline to its isopolylproline equivalent. This conversion is critical for the regulation of protein stability and dynamics, as the isopolylproline equivalent is more stable than proline and can be involved in various cellular processes, including cell signaling, DNA replication, and protein-protein interactions.

PPIAP46 is involved in various cellular processes, including the regulation of protein stability and dynamics, cell signaling, and DNA replication. It is a key enzyme in the regulation of the stability of various proteins, including the cytoskeleton, actinin, and neurotransmitters.

In addition to its role in protein regulation, PPIAP46 is also involved in the regulation of its own stability. Studies have shown that PPIAP46 can be targeted by various degradation pathways, including autophagy and ubiquitin-proteasome-mediated degradation. This suggests that PPIAP46 may play a role in the regulation of its own stability and may be a potential drug target.

Drug Targeting and Biomarker Potential

Several studies have identified PPIAP46 as a potential drug target due to its unique structure and its involvement in various cellular processes. PPIAP46 has been shown to be involved in the regulation of protein stability and dynamics, making it an attractive target for small molecules that can modulate these processes.

In addition to its potential as a drug target, PPIAP46 has also been identified as a potential biomarker for various diseases. The regulation of PPIAP46 activity is involved in the regulation of various cellular processes, including cell signaling, DNA replication, and protein-protein interactions. This suggests that changes in PPIAP46 activity

Protein Name: Peptidylprolyl Isomerase A Pseudogene 46

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The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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