Potential Drug Target and Biomarker for PPM1D (G8493)

Target Name: PPM1D

NCBI ID: G8493

PPM1D

Potential Drug Target and Biomarker for PPM1D

PPM1D (PPM1D-HUMAN) is a protein that is expressed in human tissues and has been identified as a potential drug target in the field of cancer. The protein is derived from the human proteasome, which is a complex of proteins that break down other proteins into smaller pieces. PPM1D has been shown to play a role in the regulation of cell proliferation and has been linked to the development and progression of various diseases, including cancer.

The PPM1D Protein

PPM1D is a 24-kDa protein that is expressed in various tissues of the body, including the brain, lung, liver, and gastrointestinal tract. It is composed of a unique nucleotide sequence that is specific to the proteasome and is expressed in a cell-type-dependent manner. PPM1D has been shown to play a role in the regulation of cellular processes such as cell adhesion, migration, and invasion, and has been linked to the development and progression of various diseases, including cancer.

PPM1D as a Drug Target

PPM1D has been identified as a potential drug target due to its involvement in the regulation of cell proliferation and its link to the development of cancer. Studies have shown that PPM1D can interact with various signaling pathways, including the PI3K/Akt signaling pathway, which is known to play a role in the regulation of cell proliferation and survival.

One of the most promising aspects of PPM1D as a drug target is its potential to target a wide range of diseases, including cancer. due to its involvement in cell proliferation and its specificity to certain cell types, PPM1D has the potential to be a valuable drug target for a variety of diseases.

Another promising aspect of PPM1D is its ability to be targeted using small molecules, such as inhibitors, due to its high protein expression and its unique nucleotide sequence. This allows for the development of compounds that specifically target PPM1D and can be used to treat diseases where specificity is a high priority.

PPM1D as a Biomarker

PPM1D has also been identified as a potential biomarker for the diagnosis and prognosis of various diseases, including cancer. Studies have shown that the expression of PPM1D is associated with the development and progression of cancer and can be used as a biomarker for disease progression.

In addition, PPM1D has also been shown to be a potential biomarker for the response to anti-cancer drugs. This is due to its involvement in cell proliferation and its ability to interact with signaling pathways that are known to be affected by anti-cancer drugs.

Conclusion

PPM1D is a protein that has been identified as a potential drug target and biomarker for the regulation of cell proliferation and the development and progression of various diseases, including cancer. Its unique nucleotide sequence and its involvement in various cellular processes make it an attractive target for small molecules. Further research is needed to fully understand the role of PPM1D as a drug target and biomarker and its potential to be used in the treatment of various diseases.

Protein Name: Protein Phosphatase, Mg2+/Mn2+ Dependent 1D

Functions: Involved in the negative regulation of p53 expression (PubMed:23242139). Required for the relief of p53-dependent checkpoint mediated cell cycle arrest. Binds to and dephosphorylates 'Ser-15' of TP53 and 'Ser-345' of CHEK1 which contributes to the functional inactivation of these proteins (PubMed:15870257, PubMed:16311512). Mediates MAPK14 dephosphorylation and inactivation (PubMed:21283629). Is also an important regulator of global heterochromatin silencing and critical in maintaining genome integrity (By similarity)

The "PPM1D Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about PPM1D comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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