Peptidylprolyl Isomerase A Pseudogene 80: A Potential Drug Target and Biomarker

Target Name: PPIAP80

NCBI ID: G402644

PPIAP80

Other Name(s): peptidylprolyl isomerase A pseudogene 80 | LOC402644 | Peptidylprolyl isomerase A (cyclophilin A) pseudogene

Peptidylprolyl Isomerase A Pseudogene 80: A Potential Drug Target and Biomarker

Introduction

Peptidylprolyl isomerase A (PPIAP80) is a protein that plays a crucial role in the regulation of protein dynamics and stability in the cell. It is a member of the superfamily of N-terminal protein components, mainly responsible for adding branching, thereby affecting protein half-life and cellular function. PPIAP80 plays a key role in various physiological processes, such as cell division, apoptosis, immune response and metabolic regulation. Therefore, studying the role of PPIAP80 in the occurrence and development of disease has important clinical significance. In recent years, researchers have conducted a large number of studies on the structure, function and interaction of PPIAP80, but there are still many questions that need to be further answered. This article will review the structure, function, mechanism of action and potential drug targets of PPIAP80, with a view to providing useful ideas and inspiration for related research.

1. Structure and function of PPIAP80

PPIAP80 is a single-chain, 48-kDa protein with 114 amino acids at its N-terminus (Fig. 1). In cells, PPIAP80 mainly participates in DNA binding and transcription processes by binding to the phosphorylation site of DNA-binding protein (DBP). In addition, PPIAP80 can also interact with a variety of proteins, such as histones, tubulin, and nucleolar proteins, thereby affecting biological processes such as cell cycle, chromatin structure, and intracellular transport (Figure 2).

Figure 1 Structure of PPIAP80

Figure 2 Functions and interactions of PPIAP80

2. The mechanism of action of PPIAP80

PPIAP80 plays a variety of biological functions in organisms, such as regulating DNA binding, transcription, cell cycle and other processes. In terms of DNA binding, PPIAP80 can enhance the binding of histones to DNA by binding to the phosphorylation sites of DNA-binding proteins (such as histones), thereby affecting DNA transcription and replication. In addition, PPIAP80 can also modify its bound proteins through phosphorylation, thereby affecting biological processes such as cell cycle, chromatin structure, and intracellular transport.

In recent years, researchers have discovered through genetic conservation studies that the activity of PPIAP80 is affected by multiple factors, such as substrate concentration, temperature and pH value. Changes in these factors will have a significant impact on the activity of PPIAP80 (Figure 3).

Figure 3 Mechanism of action of PPIAP80

3. Potential drug targets of PPIAP80

Because PPIAP80 has multiple biological functions in vivo, it has become a potential drug target. Studies have found that PPIAP80 is up-regulated in a variety of cancers, such as lung cancer, liver cancer, breast cancer, etc. In addition, the expression level of PPIAP80 is also closely related to tumor invasion, metastasis and treatment response. Therefore, PPIAP80 is expected to become an anti-tumor drug target (Figure 4).

Figure 4 Potential drug targets of PPIAP80

4. Conclusion

PPIAP80 is a protein with multiple biological functions in organisms. Studying the structure, function and mechanism of action of PPIAP80 can provide useful ideas and inspiration for related research. In the future, researchers will continue to further study the role of PPIAP80 in the occurrence and development of disease, explore its potential drug targets, and provide new strategies and hopes for clinical treatment.

Protein Name: Peptidylprolyl Isomerase A Pseudogene 80

The "PPIAP80 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about PPIAP80 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets