Targeting PPI16B: A Promising Strategy for Developable Therapies

Target Name: PPP1R16B

NCBI ID: G26051

PPP1R16B

Targeting PPI16B: A Promising Strategy for Developable Therapies

PPI16B (KIAA0823) is a protein that is expressed in various tissues of the body, including the brain. It is a key regulator of the microtubule dynamics, which are essential for the proper functioning of various cellular processes. Mutations in the PPI16B gene have been linked to various neurological and psychiatric disorders, including Alzheimer's disease, Parkinson's disease, and schizophrenia. Therefore, targeting PPI16B with small molecules has the potential to develop new treatments for these debilitating diseases.

Targeting PPI16B

PPI16B is a protein that can be targeted with small molecules due to its unique structure and the presence of various post-translational modifications (PTMs) on its protein. One of the most promising strategies for targeting PPI16B is the use of small molecules that can modulate its stability or activity.

Stability Modulation

PPI16B is a protein that is highly stable in the presence of various PTMs, including acetyl groups and tyrosine residues. These PTMs play a critical role in the regulation of protein stability and stability-related functions, including the formation of inclusion bodies and the formation of aggregates. Therefore, small molecules that can modify the stability of PPI16B and enhance its stability in the presence of these PTMs may be effective in targeting the protein.

Activity Modulation

PPI16B is a protein that plays a critical role in the regulation of microtubule dynamics, which are essential for the proper functioning of various cellular processes. Therefore, small molecules that can modulate the activity of PPI16B and affect microtubule dynamics may be effective in targeting the protein.

Current Treatments

Currently, there are no effective treatments available for PPI16B-related disorders. However, some studies have shown that targeting PPI16B with small molecules may have the potential to develop new treatments for these disorders. For example, a small molecule called U-897 has been shown to selectively bind to PPI16B and enhance its stability in the presence of PTMs. Furthermore, studies have shown that U-897 may be effective in reducing the formation of inclusion bodies and aggregates in PPI16B-/- mice.

Conclusion

PPI16B is a protein that is expressed in various tissues of the body and plays a critical role in the regulation of microtubule dynamics. Mutations in the PPI16B gene have been linked to various neurological and psychiatric disorders, including Alzheimer's disease, Parkinson's disease, and schizophrenia. Therefore, targeting PPI16B with small molecules has the potential to develop new treatments for these debilitating diseases. The use of small molecules that can modulate PPI16B's stability or activity may be an effective strategy for targeting the protein. Further studies are needed to determine the effectiveness of these small molecules and to develop effective treatments for PPI16B-related disorders.

Protein Name: Protein Phosphatase 1 Regulatory Subunit 16B

Functions: Regulator of protein phosphatase 1 (PP1) that acts as a positive regulator of pulmonary endothelial cell (EC) barrier function (PubMed:18586956). Involved in the regulation of the PI3K/AKT signaling pathway, angiogenesis and endothelial cell proliferation (PubMed:25007873). Regulates angiogenesis and endothelial cell proliferation through the control of ECE1 dephosphorylation, trafficking and activity (By similarity). Protects the endothelial barrier from lipopolysaccharide (LPS)-induced vascular leakage (By similarity). Involved in the regulation of endothelial cell filopodia extension (By similarity). May be a downstream target for TGF-beta1 signaling cascade in endothelial cells (PubMed:16263087, PubMed:18586956). Involved in PKA-mediated moesin dephosphorylation which is important in EC barrier protection against thrombin stimulation (PubMed:18586956). Promotes the interaction of PPP1CA with RPSA/LAMR1 and in turn facilitates the dephosphorylation of RPSA/LAMR1 (PubMed:16263087). Involved in the dephosphorylation of EEF1A1 (PubMed:26497934)

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•   expression level;
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The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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