DPP8: A Protein Involved in Various Physiological Processes and as A Potential Drug Target Or Biomarker

Target Name: DPP8

NCBI ID: G54878

DPP8

DPP8: A Protein Involved in Various Physiological Processes and as A Potential Drug Target Or Biomarker

DPP8 (Dipeptidyl-peptidase VIII) is a protein that is expressed in various tissues throughout the body, including the liver, pancreas, and muscle. It is a member of the superfamily of serine endopeptidases, which are a group of enzymes that remove the peptidyl endings from proteins. This protein is unique in that it is both catalytic and substrate- specific, meaning it can not only break down the peptidyl endings of proteins, but it can also cleave specific amino acids at specific sites along the protein sequence.

DPP8 is involved in a wide range of physiological processes in the body, including the digestion and absorption of nutrients, as well as the regulation of inflammation and cell signaling. It is often used as a drug target or biomarker in various diseases, including diabetes, cancer, and neurodegenerative disorders.

One of the most significant functions of DPP8 is its role in the digestion of proteins. It is found in the intestinal tract, where it breaks down the peptidyl endings of proteins that are too large to be absorbed by the body. This process is important for the absorption of nutrients such as protein, carbohydrates, and fats, which are essential for maintaining the health and function of the body.

In addition to its role in protein digestion, DPP8 is also involved in the regulation of inflammation and cell signaling. It has been shown to play a key role in the development and progression of various inflammatory diseases, including diabetes and cancer. It is also involved in the regulation of cell signaling, particularly in the signaling pathway known as the TGF-β pathway. This pathway is involved in the regulation of cell growth, differentiation, and survival, and is a key factor in the development of many diseases, including cancer.

DPP8 is also a potential biomarker for several diseases, including diabetes and cancer. Its role in these diseases is related to its function in protein digestion and cell signaling. For example, DPP8 has been shown to be involved in the regulation of insulin sensitivity and glucose metabolism, which are important factors in the development of diabetes. It is also involved in the regulation of cell signaling, which is important in the development of cancer.

In conclusion, DPP8 is a protein that is involved in a wide range of physiological processes in the body. It is a member of the superfamily of serine endopeptidases and is both catalytic and substrate- specific. Its role in protein digestion and cell signaling makes it an important protein for understanding the development and progression of various diseases. Further research is needed to fully understand the functions of DPP8 and its potential as a drug target or biomarker.

Protein Name: Dipeptidyl Peptidase 8

Functions: Dipeptidyl peptidase that cleaves off N-terminal dipeptides from proteins having a Pro or Ala residue at position 2 (PubMed:11012666, PubMed:12534281, PubMed:12662155, PubMed:15039077, PubMed:15664838, PubMed:20536396, PubMed:29382749). Acts as a key inhibitor of caspase-1-dependent monocyte and macrophage pyroptosis in resting cells by preventing activation of NLRP1 and CARD8 (PubMed:27820798, PubMed:29967349, PubMed:32796818). Sequesters the cleaved C-terminal part of NLRP1 and CARD8, which respectively constitute the active part of the NLRP1 and CARD8 inflammasomes, in a ternary complex, thereby preventing their oligomerization and activation (PubMed:34019797, PubMed:33731929, PubMed:33731932). The dipeptidyl peptidase activity is required to suppress NLRP1 and CARD8; however, neither NLRP1 nor CARD8 are bona fide substrates of DPP8, suggesting the existence of substrate(s) required for NLRP1 and CARD8 inhibition (By similarity)

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•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
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•   the target screening and validation;
•   expression level;
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The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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