DPYSL5: A Potential Drug Target and Biomarker for Collapsin Response Mediator Protein-5

Target Name: DPYSL5

NCBI ID: G56896

DPYSL5

DPYSL5: A Potential Drug Target and Biomarker for Collapsin Response Mediator Protein-5

Introduction

Collapsin response mediator protein-5 (DPYSL5) is a protein that plays a crucial role in cell signaling pathways, particularly in the regulation of cell division and growth. It is a key mediator of the collapsin response, a critical event in the cell cycle that leads to the formation of new nuclear structures during theG1 phase of cell division. The dysregulation ofDPYSL5 has been implicated in various diseases, including cancer, neurodegenerative diseases, and developmental disorders. As a result, targetingDPYSL5 has emerged as a promising strategy for the development of new treatments. In this article, we will discussDPYSL5 as a drug target and biomarker.

DPYSL5: Structure and Function

DPYSL5 is a 21 kDa protein that belongs to the family of APC/CAP-associated proteins. It is expressed in various tissues and cells, including skeletal muscles, nerve fibers, heart muscle, and cancer cells. DPYSL5 is composed of an N-terminal transmembrane domain, a catalytic domain, and a C-terminal TIR domain.

The N-terminal transmembrane domain is responsible for the protein's ability to interact with various cell signaling pathways. It contains a putative G-protein-coupled receptor (GPCR) domain, which is known to participate in the regulation of cell proliferation and differentiation.

The catalytic domain is the site ofDPYSL5's enzymatic activity. It contains a catalytic active center, which is responsible for the chemical reaction that links the protein to its ligand, such as DNA or RNA.

The C-terminal TIR domain is a structural domain that is involved in the regulation ofDPYSL5's stability and interactions with other cellular components.

DPYSL5 has been shown to play a critical role in the regulation of cell division and growth. It is a potent inhibitor of the cyclin D1-CDK4 complex, which is responsible for regulating the G1 phase of the cell cycle. InG1 phase,DPYSL5 can interact with the transcription factorp21 (TPF), leading to the inhibition of its DNA binding activity. This interaction between DPYSL5 and TPF is critical for the regulation of cell growth and the maintenance of cellular homeostasis.

In addition to its role in cell signaling pathways,DPYSL5 has also been shown to play a significant role in the regulation of cell death. In various cellular models,DPYSL5 has been shown to be involved in the regulation of apoptosis, which is a critical event in the regulation of cell number and survival.

DPYSL5 as a Drug Target

The potential ofDPYSL5 as a drug target is based on its involvement in various cellular signaling pathways and its critical role in the regulation of cell division and growth. Various studies have shown that inhibition ofDPYSL5 can lead to the inhibition of cellular growth and the regulation of cell death, which can be beneficial for the development of new treatments for various diseases.

One of the potential strategies for targeting DPYSL5 is the inhibition of its catalytic activity using small molecules or antibodies. These molecules can interact with DPYSL5 and prevent its catalytic activity, leading to the inhibition of cell growth and the regulation of cell death.

Another strategy for targeting DPYSL5 is the use of drugs that specifically target its N-terminal transmembrane domain. These drugs can interact with DPYSL5 and prevent its interaction with various cell signaling pathways, leading to the inhibition of cell growth and the regulation of cell death.

DPYSL5 as a Biomarker

DPYSL5 can also be used as a biomarker for various diseases. Its involvement in the regulation of cell division and growth makes it an attractive candidate for the diagnosis and prognosis of certain diseases. For example, the dysregulation ofDPYSL5 has

Protein Name: Dihydropyrimidinase Like 5

Functions: Involved in the negative regulation of dendrite outgrowth

The "DPYSL5 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about DPYSL5 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets