PARPBP: Key Regulator of DNA Damage Repair (G55010)

Target Name: PARPBP

NCBI ID: G55010

PARPBP

PARPBP: Key Regulator of DNA Damage Repair

PARPBP (PARP1 binding protein) is a protein that is expressed in various tissues throughout the body. It is a key regulator of the DNA damage response, which is a critical process that helps the body repair damage to its DNA. PARPBP plays a crucial role in the regulation of DNA repair by binding to the protein PARP1, which is a key component of the DNA damage repair machinery.

The DNA damage repair system is a complex network of proteins that work together to repair damage to DNA. When DNA is damaged, the cell enters a state of stress, and the DNA damage repair system is activated to repair the damage. The PARPBP protein is a key regulator of this process.

PARPBP is a protein that is composed of 11 kDa伪 and 4 kDa尾 subunits. The 伪 subunit consists of a single polypeptide chain that contains a variety of functional domains, including a N-terminal domain that is involved in protein-protein interactions and a C-terminal domain that contains a conserved Asp-Glu-Asp loop. The 尾 subunit consists of a single polypeptide chain that contains a variable region at its C-terminus that is involved in protein-protein interactions.

The PARPBP protein plays a crucial role in the regulation of the DNA damage repair system. It is well established that DNA damage can cause changes in the structure and function of proteins, and these changes can have a negative impact on the function of the cell. PARPBP helps to prevent these changes by binding to the protein PARP1 and regulating the activity of the DNA damage repair machinery.

One of the key functions of PARPBP is its ability to bind to PARP1. PARP1 is a protein that is composed of two subunits: a 25 kDa伪 subunit and a 1 kDa尾 subunit. The 25 kDa伪 subunit contains a conserved N-terminal domain that is involved in protein-protein interactions, and the 1 kDa尾 subunit contains a variable region at its C-terminus that is involved in protein-protein interactions.

When DNA is damaged, the PARP1 protein is recruited to the site of the damage and interacts with the PARPBP protein. This interaction between PARP1 and PARPBP is critical for the regulation of the DNA damage repair system. PARPBP helps to recruit PARP1 to the site of the damage and then regulates the activity of the DNA damage repair machinery.

One of the key functions of PARPBP is its ability to regulate the activity of the DNA damage repair machinery. The DNA damage repair machinery is a complex network of proteins that work together to repair damage to DNA. The PARPBP protein helps to regulate the activity of these proteins by binding to their active sites and preventing them from interacting with DNA.

PARPBP also plays a key role in the regulation of DNA replication. DNA replication is a critical process that is essential for the growth and development of all cells. The PARPBP protein helps to regulate the activity of the DNA replication machinery by binding to the protein DNAA1 and preventing it from interacting with DNA.

In conclusion, PARPBP (PARP1 binding protein) is a protein that is essential for the regulation of the DNA damage repair system. It plays a crucial role in the Recruitment of PARP1 to the site of DNA damage, regulation of DNA damage repair machinery and DNA replication. The PARPBP protein is a potential drug target or biomarker and could be a valuable tool for the development of new treatments for DNA damage-related diseases.

Protein Name: PARP1 Binding Protein

Functions: Required to suppress inappropriate homologous recombination, thereby playing a central role DNA repair and in the maintenance of genomic stability. Antagonizes homologous recombination by interfering with the formation of the RAD51-DNA homologous recombination structure. Binds single-strand DNA and poly(A) homopolymers. Positively regulate the poly(ADP-ribosyl)ation activity of PARP1; however such function may be indirect

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