PRMT6: The Potential Drug Target and Biomarker for Prostate and Lung Cancer

Target Name: PRMT6

NCBI ID: G55170

PRMT6

PRMT6: The Potential Drug Target and Biomarker for Prostate and Lung Cancer

Prostate and lung cancer are two of the leading causes of cancer-related deaths worldwide. The development of new treatments and drug targets is crucial for improving survival rates and managing the disease. PRMT6 is a protein arginine methyltransferase 6 that has been identified as a potential drug target and biomarker for prostate and lung cancer. In this article, we will discuss the potential benefits of PRMT6 as a drug target and biomarker for prostate and lung cancer.

The Role of PRMT6 in Prostate Cancer

Prostate cancer is the most common cancer in men, and its incidence is increasing every year. The majority of prostate cancers are prostate-specific adenocarcinoma, which develops from the prostate glandular tissue. The growth of prostate cancer is fueled by the uncontrolled cell growth that occurs within the prostate tissue. PRMT6 is a key enzyme in the regulation of cell growth and division, and its inhibition could be a promising strategy for the treatment of prostate cancer.

Studies have shown that PRMT6 levels are significantly increased in prostate cancer tissues compared to the surrounding tissue. Additionally, inhibition of PRMT6 has been shown to reduce the growth of prostate cancer cells in cell culture and animal models. This suggests that PRMT6 may be a promising target for the treatment of prostate cancer.

The Potential Role of PRMT6 as a Biomarker

PRMT6 is also a potential biomarker for prostate cancer. The majority of prostate cancers are diagnosed through biopsy, which can be a invasive and potentially risky procedure. Developing a non-invasive diagnostic tool for prostate cancer could have a significant impact on patient outcomes. PRMT6 has been shown to be expressed in various types of cancer, including prostate cancer.

In addition, changes in PRMT6 levels have been observed in response to various treatment options for prostate cancer. For example, inhibition of PRMT6 has been shown to reduce the risk of recurrence in prostate cancer patients treated with traditional hormone therapies. Additionally, PRMT6 has been shown to be downregulated in response to chemotherapy, which could make it an attractive target for cancer immunotherapy.

The Potential Benefits of PRMT6 as a Drug Target

PRMT6 has the potential to be a drug target for prostate and lung cancer due to its unique mechanism of action. PRMT6 plays a critical role in the regulation of cell growth and division by modulating the levels of arginine in the cell. By inhibiting PRMT6, researchers have shown that they can reduce the growth of cancer cells in both prostate and lung cancer models.

In addition, PRMT6 has been shown to be involved in the development of resistance to traditional cancer therapies. This suggests that its inhibition could be a promising strategy for the treatment of cancer that is currently resistant to standard therapies.

The Potential Risks of PRMT6 as a Drug Target

While PRMT6 has the potential to be a drug target for prostate and lung cancer, there are also several potential risks to consider. One of the main concerns is the potential impact on normal cell function. PRMT6 plays a critical role in the regulation of cell growth and division, and its inhibition could have unintended consequences for the normal functioning of cells.

Another potential risk is the potential for PRMT6 to contribute to the development of resistance to cancer therapies. As with any drug target, its inhibition could lead to the emergence of new mechanisms of cancer resistance.

Conclusion

PRMT6 is a protein arginine methyltransferase 6 that has been identified as a potential drug target and biomarker for prostate and lung cancer. Its inhibition has been shown to reduce the growth of cancer cells in cell culture and animal models, making it a promising target for the treatment of these

Protein Name: Protein Arginine Methyltransferase 6

Functions: Arginine methyltransferase that can catalyze the formation of both omega-N monomethylarginine (MMA) and asymmetrical dimethylarginine (aDMA), with a strong preference for the formation of aDMA (PubMed:17898714, PubMed:18077460, PubMed:18079182, PubMed:19405910, PubMed:30420520). Preferentially methylates arginyl residues present in a glycine and arginine-rich domain and displays preference for monomethylated substrates (PubMed:17898714, PubMed:18077460, PubMed:18079182, PubMed:19405910). Specifically mediates the asymmetric dimethylation of histone H3 'Arg-2' to form H3R2me2a (PubMed:17898714, PubMed:18079182, PubMed:18077460). H3R2me2a represents a specific tag for epigenetic transcriptional repression and is mutually exclusive with methylation on histone H3 'Lys-4' (H3K4me2 and H3K4me3) (PubMed:17898714, PubMed:18077460). Acts as a transcriptional repressor of various genes such as HOXA2, THBS1 and TP53 (PubMed:19509293). Repression of TP53 blocks cellular senescence (By similarity). Also methylates histone H2A and H4 'Arg-3' (H2AR3me and H4R3me, respectively). Acts as a regulator of DNA base excision during DNA repair by mediating the methylation of DNA polymerase beta (POLB), leading to the stimulation of its polymerase activity by enhancing DNA binding and processivity (PubMed:16600869). Methylates HMGA1 (PubMed:16157300, PubMed:16159886). Regulates alternative splicing events. Acts as a transcriptional coactivator of a number of steroid hormone receptors including ESR1, ESR2, PGR and NR3C1. Promotes fasting-induced transcriptional activation of the gluconeogenic program through methylation of the CRTC2 transcription coactivator (By similarity). May play a role in innate immunity against HIV-1 in case of infection by methylating and impairing the function of various HIV-1 proteins such as Tat, Rev and Nucleocapsid protein p7 (NC) (PubMed:17267505). Methylates GPS2, protecting GPS2 from ubiquitination and degradation (By similarity). Methylates SIRT7, inhibiting SIRT7 histone deacetylase activity and promoting mitochondria biogenesis (PubMed:30420520)

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•   protein biological mechanisms;
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•   the target screening and validation;
•   expression level;
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The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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