POLR3E: A Regulator of Gene Expression and RNA Homeostasis (G55718)

Target Name: POLR3E

NCBI ID: G55718

POLR3E

POLR3E: A Regulator of Gene Expression and RNA Homeostasis

POLR3E (poly (A-lingutivirin-1) RNA-protein interactions with RNA-protein interactions) is a protein that is expressed in various cell types of the human body, including the brain, heart, liver, and kidneys. It is a 24 kDa protein that consists of a 196 amino acid chain. The protein is involved in the regulation of gene expression by binding to specific RNA molecules.

POLR3E is a key regulator of gene expression in various cell types, and it has been implicated in the development and progression of many diseases. For example, studies have shown that high levels of POLR3E are associated with the development of cancer, and that its expression is downregulated in cancer cells.

In addition to its role in gene expression, POLR3E has also been shown to play a role in the regulation of RNA homeostasis. This is the balance between the amount of RNA produced and the amount of RNA degradation, and it is critical for the stability and quality of RNA. Studies have shown that POLR3E plays a role in regulating the stability of pre-mRNA, which are the RNA molecules that are produced from the DNA but are not yet translated into proteins.

Another function of POLR3E is its role in the regulation of post-transcriptional modification of RNA. This is a process by which the RNA molecule is modified after it has been synthesized, and it is important for the stability and quality of RNA. Studies have shown that POLR3E plays a role in the modification of RNA by binding to specific RNA molecules and modifying their stability.

In conclusion, POLR3E is a protein that is involved in the regulation of gene expression, RNA homeostasis, and post-transcriptional modification of RNA. Its expression is downregulated in many diseases, including cancer, and it is a potential drug target or biomarker. Further research is needed to fully understand the role of POLR3E in disease development and progression.

Protein Name: RNA Polymerase III Subunit E

Functions: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Essential for efficient transcription from both the type 2 VAI and type 3 U6 RNA polymerase III promoters. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway (By similarity)

The "POLR3E Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about POLR3E comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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