PSMD5: A Protein Involved in Cell Signaling and Cell Death (G5711)

Target Name: PSMD5

NCBI ID: G5711

PSMD5

PSMD5: A Protein Involved in Cell Signaling and Cell Death

PSMD5 (Proteasome-Mediated Secretory Mammalian Degradation) is a protein that is expressed in various tissues of the human body, including the brain, pancreas, and gastrointestinal tract. It is involved in the degradation of a variety of biomolecules, including proteins, RNA, and vesicles. In addition, PSMD5 has been shown to play a role in the regulation of cellular processes, such as cell signaling and autophagy.

The PSMD5 protein is composed of 120 amino acids and has a calculated molecular mass of 13.9 kDa. It is expressed in a variety of tissues and cells in the human body, including the brain, pancreas, and gastrointestinal tract. PSMD5 is primarily localized to the endoplasmic reticulum (ER), where it can be detected by techniques such as immunofluorescence and Western blotting.

PSMD5 has been shown to play a role in the regulation of cellular processes, such as cell signaling and autophagy. For example, studies have shown that PSMD5 can interact with the protein ubiquitin and can modulate the activity of the ubiquitin-proteasome system (UPS). This suggests that PSMD5 may be involved in the degradation of Ubiquitin, a protein that plays a role in the regulation of cellular processes and is involved in a variety of diseases, including cancer.

In addition, PSMD5 has also been shown to play a role in the regulation of cellular apoptosis (programmed cell death). Studies have shown that PSMD5 can interact with the protein Bcl-2 and can modulate the activity of the Bcl-2-associated protein (BAP) in a variety of cell types. This suggests that PSMD5 may be involved in the regulation of cell death, which is a critical process for the maintenance of tissue homeostasis and the regulation of various physiological processes.

PSMD5 has also been shown to play a role in the regulation of cellular signaling pathways. For example, studies have shown that PSMD5 can interact with the protein Phospho-ERK1 (p-ERK1), which is a protein that is involved in the regulation of cellular signaling pathways. This suggests that PSMD5 may be involved in the regulation of signaling pathways that are involved in cellular processes, such as cell growth, differentiation, and survival.

In conclusion, PSMD5 is a protein that is expressed in various tissues of the human body and has been shown to play a role in the regulation of cellular processes, including cell signaling and autophagy. Its function and structure suggest that PSMD5 may be a drug target or biomarker for a variety of diseases. Further research is needed to fully understand the role of PSMD5 in cellular processes and its potential as a therapeutic target.

Protein Name: Proteasome 26S Subunit, Non-ATPase 5

Functions: Acts as a chaperone during the assembly of the 26S proteasome, specifically of the base subcomplex of the PA700/19S regulatory complex (RC). In the initial step of the base subcomplex assembly is part of an intermediate PSMD5:PSMC2:PSMC1:PSMD2 module which probably assembles with a PSMD10:PSMC4:PSMC5:PAAF1 module followed by dissociation of PSMD5

The "PSMD5 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about PSMD5 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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