PGR2: Pain, Inflammation and Cell Survival Regulator (G145482)

Target Name: PTGR2

NCBI ID: G145482

PTGR2

PGR2: Pain, Inflammation and Cell Survival Regulator

Prostaglandin (PG) is a family of potent regulators of pain, inflammation, and uterine contractions. The prostaglandin system has been implicated in numerous diseases, including arthritis, asthma, and cancer. One of the enzymes involved in the prostaglandin pathway is prostaglandin reductase 2 (PGR2), which plays a crucial role in breaking down PGs and regulating their production.

PGR2 is a transmembrane protein that localized to the endoplasmic reticulum (ER) and the cytoplasm. It is a potent inhibitor of PGR2-catalyzed reactions, and it regulates the levels of various PGs in the body. PGR2 has been shown to play a key role in the regulation of pain, inflammation, and uterine contractions.

One of the well-documented functions of PGR2 is its role in pain modulation. PGR2 has been shown to reduce pain sensitivity in animal models of pain. For example, PGR2-/- mice have a reduced sensitivity to thermal and chemical pain when compared to wild-type (WT) mice. Additionally, PGR2 has been shown to modulate pain-related neurocircuits in the brain, suggesting that it may play a role in the neural mechanisms of pain.

PGR2 also plays a key role in the regulation of inflammation. It has been shown to reduce the production of pro-inflammatory cytokines in response to tissue damage or infection, and to reduce the size of inflammatory granules in the site of inflammation. This may help to prevent the progression of inflammation and reduce the severity of inflammatory-related diseases.

In addition to its role in pain and inflammation, PGR2 has also been implicated in several other physiological processes. For example, it has been shown to regulate cell proliferation and survival, and to modulate the production of cell-surface proteins involved in cell-cell signaling. PGR2 may also play a role in regulating the production of extracellular matrix (ECM) components, such as collagen, which are involved in tissue mechanics and integrity.

Despite its widespread involvement in various physiological processes, the precise function of PGR2 is not well understood. While several studies have identified PGR2 as a potential drug target in various organisms, the precise mechanism of its action remains a mystery. One possible mechanism of PGR2's action may be its role as a negative regulator of pro-inflammatory pathways. By inhibiting the production of pro-inflammatory cytokines and limiting the size of inflammatory granules, PGR2 may help to prevent the progression of inflammation and reduce the severity of inflammatory-related diseases.

Another potential mechanism of PGR2's action may be its role as a regulator of cell survival and proliferation. By regulating cell proliferation and survival, PGR2 may help to maintain the homeostasis of cells and prevent the formation of cancerous tumors. Additionally, PGR2 may also play a role in regulating cell-cell signaling, which is important for the proper functioning of tissues and organs.

In conclusion, PGR2 is a well-documented protein that plays a crucial role in the prostaglandin system and the regulation of pain, inflammation, and uterine contractions. Its functions are still largely unexplored, but its potential as a drug target or biomarker makes it an attractive target for future research. Further studies are needed to fully understand the precise mechanism of PGR2's action and its potential as a therapeutic agent.

Protein Name: Prostaglandin Reductase 2

Functions: Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-keto-PGE1, 15-keto-PGE2, 15-keto-PGE1-alpha and 15-keto-PGE2-alpha with highest activity towards 15-keto-PGE2 (PubMed:19000823). Overexpression represses transcriptional activity of PPARG and inhibits adipocyte differentiation (By similarity)

The "PTGR2 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about PTGR2 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets