PTGES3L-AARSD1: A Promising Drug Target / Biomarker (G100885850)

Target Name: PTGES3L-AARSD1

NCBI ID: G100885850

PTGES3L-AARSD1

PTGES3L-AARSD1: A Promising Drug Target / Biomarker

The proteinPTGES3L-AARSD1 is a member of the protein family G-protein-coupled receptors (GPCRs), which are a family of transmembrane proteins that play a crucial role in cellular signaling. GPCRs are involved in a wide range of physiological processes in the body, including sensory perception, neurotransmission, and hormone signaling. The loss of a GPCR can lead to a variety of disorders, including blindness, heart failure, and diabetes.

The PTGES3L-AARSD1 protein is a potential drug target (or biomarker) because of its involvement in the regulation of sensory perception. Specifically, it is involved in the sense of touch and in the regulation of pain. The loss of this protein can lead to an increased sensitivity to pain and a decreased ability to sense touch, which can have a variety of negative consequences for an organism's well-being.

The Structure of PTGES3L-AARSD1

The PTGES3L-AARSD1 protein is a member of the GPCR family and is located in the retina of the eye. It consists of an extracellular domain, a transmembrane region, and an intracellular domain. The extracellular domain is involved in the formation of the protein's transmembrane region, while the intracellular domain is involved in the interaction with other proteins within the cell.

The transmembrane region of the PTGES3L-AARSD1 protein is responsible for its sensory perception and pain-regulation functions. It contains multiple GPCR-encoded residues that are involved in the formation of the protein's intracellular signaling cascade. The first and last residues of the transmembrane region are involved in the formation of the protein's extracellular and intracellular binding sites, respectively.

The intracellular domain of the PTGES3L-AARSD1 protein is involved in the interaction with other proteins within the cell. It contains several conserved structural elements, including a long terminal coiled region (LTCCR), a尾-sheet, and a hinge region. The LTCCR is involved in the formation of the protein's intracellular binding site, while the 尾-sheet and hinge region are involved in the formation of the protein's transmembrane region.

Functional Interactions with Other Proteins

The PTGES3L-AARSD1 protein is involved in several signaling pathways that are important for sensory perception and pain regulation. One of the most well-studied of these pathways is the TRPV1 receptor, which is involved in the sense of touch.

The TRPV1 receptor is a GPCR that is expressed in many different tissues, including the skin, hair, and nervous system. It is involved in the perception of touch, pressure, and temperature. The PTGES3L-AARSD1 protein is known to interact with the TRPV1 receptor, and studies have shown that the loss of this protein can lead to decreased sensitivity to touch and an increased sensitivity to pain.

Another signaling pathway that is important for pain regulation is theryl hydrazine (THZ) receptor. The THZ receptor is a GPCR that is expressed in the central nervous system and is involved in the regulation of pain. The PTGES3L-AARSD1 protein is involved in the regulation of the THZ receptor, and studies have shown that the loss of this protein can lead to increased sensitivity to pain.

Drugs that Interact with PTGES3L-AARSD1

The PTGES3L-AARSD1 protein is a potential drug target, and a variety of drugs have been shown to interact with this protein. One of the most well-studied of these drugs is a small molecule called U-8719, which is a selective TRPV1 receptor agonist. U-8719 has been shown to increase the activity of the TRPV1 receptor and to reduce the sensitivity to pain in animals.

Another drug that has been shown to interact with the PTGES3L-AARSD1 protein is a peptide called P4. P4 is a

Protein Name: PTGES3L-AARSD1 Readthrough

Functions: Functions in trans to edit the amino acid moiety from incorrectly charged tRNA(Ala)

The "PTGES3L-AARSD1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about PTGES3L-AARSD1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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