Regulation of CLK4: Key Player in Cellular Processes (G57396)

Target Name: CLK4

NCBI ID: G57396

CLK4

Other Name(s): CDC-like kinase 4 | CDC like kinase 4 | CLK4_HUMAN | protein serine threonine kinase Clk4 | Dual specificity protein kinase CLK4

Regulation of CLK4: Key Player in Cellular Processes

CLK4 (CDC-like kinase 4) is a protein that is expressed in various tissues throughout the body. It is a key regulator of cell cycle progression, and is involved in the regulation of DNA replication, cell division, and apoptosis. CLK4 is also involved in the regulation of protein synthesis, and is a negative regulator of the protein kinase B, which is involved in cell growth and survival.

CLK4 is a protein that is expressed in a variety of tissues, including muscle, heart, brain, and liver. It is a key regulator of cell cycle progression, and is involved in the regulation of DNA replication, cell division, and apoptosis. CLK4 is also involved in the regulation of protein synthesis, and is a negative regulator of the protein kinase B, which is involved in cell growth and survival.

One of the functions of CLK4 is to regulate the G1/S transition, which is the stage of cell cycle where the cell prepares for cell division. During the G1/S transition, CLK4 helps to ensure that the cell completes its necessary preparations for cell division, such as producing enough DNA for cell division and organizing the cytoskeleton.

CLK4 is also involved in the regulation of the G0/G1 transition, which is the stage of cell cycle where the cell is in a resting state. During the G0/G1 transition, CLK4 helps to ensure that the cell remains in a resting state, and that it is not motivated to begin cell division until it is necessary.

CLK4 is also involved in the regulation of apoptosis, which is the process by which a cell undergoes death. During apoptosis, CLK4 helps to ensure that the cell undergoes proper programmed cell death, which is necessary for the overall health and function of the organism.

In addition to its role in regulating cell cycle progression, CLK4 is also involved in the regulation of protein synthesis. It is a negative regulator of the protein kinase B, which is involved in cell growth and survival. This means that when B is activated, it promotes the growth and survival of the cell, but CLK4 can counter this effect by promoting the death of the cell.

CLK4 is also involved in the regulation of a variety of cellular processes, including cell adhesion, migration, and the regulation of ion channels. It is also involved in the regulation of cell signaling pathways, and is a target for a variety of drugs that are used to treat a variety of diseases.

Despite its involvement in a wide range of cellular processes, CLK4 is not well understood. There are currently no drugs that are specifically designed to target CLK4, and research is focused on understanding its function and the mechanisms that regulate its activity.

In conclusion, CLK4 is a protein that is involved in a wide range of cellular processes. It is a key regulator of cell cycle progression, and is involved in the regulation of DNA replication, cell division, and apoptosis. CLK4 is also involved in the regulation of protein synthesis, and is a negative regulator of the protein kinase B. Despite its involvement in a wide range of cellular processes, CLK4 is not well understood, and there is a need for further research to understand its function and the mechanisms that regulate its activity.

Protein Name: CDC Like Kinase 4

Functions: Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex and may be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing. Phosphorylates SRSF1 and SRSF3. Required for the regulation of alternative splicing of MAPT/TAU. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells

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