Unlocking the Potential of CPNE5 (KIAA1599) as a Drug Target and Biomarker

Target Name: CPNE5

NCBI ID: G57699

CPNE5

Unlocking the Potential of CPNE5 (KIAA1599) as a Drug Target and Biomarker

Cysteinyl-proline endopeptide (CPNE5) is a 21-kDa protein that is expressed in various tissues, including brain, heart, and skeletal muscles. It is a key component of the neurotransmitter system and has been implicated in various neurological and psychiatric disorders. The protein is expressed in low abundance and has been challenging to study due to its poor solubility and limited expression in humans. However, recent studies have identified CPNE5 as a potential drug target and biomarker, with potential implications for the treatment of various neurological and psychiatric disorders.

Drug Target Potential

CPNE5 has been identified as a potential drug target due to its unique structure and its involvement in various signaling pathways. The protein is composed of a catalytic active center and a C-terminal region that is involved in protein-protein interactions. The catalytic active center contains a distinct Rossmann-fold, which is a common structural motif that is involved in the formation of stable protein-protein bonds. This motif allows the protein to interact with other proteins and molecules, suggesting a potential role in various signaling pathways.

Several studies have suggested that CPNE5 is involved in various signaling pathways, including the regulation of neurotransmitter release, neuroinflammation, and stress. For example, studies have shown that CPNE5 is involved in the regulation of neurotransmitter release from axons in the central nervous system (CNS), which is critical for the transmission of signals between neurons. Additionally, CPNE5 has been shown to play a role in the regulation of stress responses and neuroinflammation, which can have detrimental effects on various physiological processes.

Biomarker Potential

CPNE5 has also been identified as a potential biomarker for various neurological and psychiatric disorders. The protein is expressed in low abundance in various tissues and has been shown to be decreased in various neurological disorders, including Alzheimer's disease, Parkinson's disease, and depression. This suggests that CPNE5 may be a potential biomarker for these disorders and could be used as a target for new therapies.

In addition, CPNE5 has been shown to be involved in the regulation of neurotransmitter release, which is critical for the diagnosis of various psychiatric disorders. For example, studies have shown that CPNE5 is involved in the regulation of the release of dopamine from the ventral tegmental area (VTA) in the brain, which is a key neurotransmitter involved in motivation and pleasure.

Conclusion

In conclusion, CPNE5 is a protein that has been identified as a potential drug target and biomarker for various neurological and psychiatric disorders. Its unique structure and involvement in various signaling pathways make it an attractive target for new therapies. Further studies are needed to fully understand the role of CPNE5 in the regulation of neurotransmitter release and the development of various psychiatric disorders.

Protein Name: Copine 5

Functions: Probable calcium-dependent phospholipid-binding protein that may play a role in calcium-mediated intracellular processes (By similarity). Plays a role in dendrite formation by melanocytes (PubMed:23999003)

The "CPNE5 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about CPNE5 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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