SP100: A Protein Implicated in Cellular Biology and Disease (G6672)

Target Name: SP100

NCBI ID: G6672

SP100

SP100: A Protein Implicated in Cellular Biology and Disease

SP100 (lys100b) is a protein that is expressed in various tissues throughout the body, including the brain, heart, and kidneys. It is a member of the heat shock protein (HSP) family, which are proteins that are expressed in response to increased levels of thermal stress.

SP100 is involved in a number of cellular processes that are important for cell survival and function. It plays a role in the regulation of protein synthesis and degradation, as well as in the maintenance of cellular homeostasis. It is also involved in the formation of cellular organelles, such as the endoplasmic reticulum and the mitochondria.

SP100 has also been shown to play a role in a number of diseases and conditions, including cancer, neurodegenerative diseases, and autoimmune disorders. It is often used as a potential drug target or biomarker because of its involvement in these diseases and because its regulation by various cellular signaling pathways makes it a potentially accessible target for small molecules.

One of the key challenges in studying SP100 is its complex cellular localization. SP100 is expressed in a variety of tissues and cellular organelles, and its localization to specific locations is not well understood. While research has shown that SP100 is involved in the regulation of protein synthesis and degradation, its exact cellular localization and the mechanisms that govern its distribution are not yet fully understood.

In addition to its potential drug-targeting potential, SP100 is also a potential biomarker for a number of diseases. Its expression has been observed in a variety of disease-related tissues and conditions, including cancer, neurodegenerative diseases, and autoimmune disorders. Additionally, its regulation by various cellular signaling pathways makes it a potentially accessible target for small molecules that could be used to diagnose and treat these diseases.

Overall, SP100 is a protein that has significant implications for our understanding of cellular biology and disease. Its regulation by various cellular signaling pathways makes it a potentially accessible target for small molecules, and its complex cellular localization and involvement in a variety of diseases make it a promising biomarker for diagnostic and therapeutic applications. Further research is needed to fully understand the mechanisms that govern its localization and function, and to develop effective strategies for its targeting and use as a drug or biomarker.

Protein Name: SP100 Nuclear Antigen

Functions: Together with PML, this tumor suppressor is a major constituent of the PML bodies, a subnuclear organelle involved in a large number of physiological processes including cell growth, differentiation and apoptosis. Functions as a transcriptional coactivator of ETS1 and ETS2 according to PubMed:11909962. Under certain conditions, it may also act as a corepressor of ETS1 preventing its binding to DNA according to PubMed:15247905. Through the regulation of ETS1 it may play a role in angiogenesis, controlling endothelial cell motility and invasion. Through interaction with the MRN complex it may be involved in the regulation of telomeres lengthening. May also regulate TP53-mediated transcription and through CASP8AP2, regulate FAS-mediated apoptosis. Also plays a role in infection by viruses, including human cytomegalovirus and Epstein-Barr virus, through mechanisms that may involve chromatin and/or transcriptional regulation

The "SP100 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about SP100 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets