SPAAR: A Potential Drug Target and Biomarker (G158376)

Target Name: SPAAR

NCBI ID: G158376

SPAAR

SPAAR: A Potential Drug Target and Biomarker

SPAAR, or small regulatory polypeptide of amino acids response, is a protein that has been identified as a potential drug target and biomarker for various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. Its unique structure and function have made it an attractive target for researchers to study, and its potential as a drug or biomarker has led to a growing interest in the field of neuroscience and immunology.

SPAAR is a protein that consists of 21 amino acids and has a molecular weight of 23.5 kDa. It has a highly conserved N-terminus and a unique C-terminus that consists of af mannosamine group, which is unique among proteins. expressed in many different tissues and cells in the body and has been shown to play a role in various physiological processes, including cell signaling, inflammation, and immune response.

One of the key features of SPAAR is its ability to interact with other proteins. SPAAR has been shown to interact with various proteins, including the transcription factor, NF-kappa-B, and the protein kinase, Akt. These interactions have been shown to play a role in the regulation of various cellular processes, including cell growth, differentiation, and inflammation.

SPAAR has also been shown to play a role in the regulation of the immune response. SPAAR has been shown to interact with the immune system protein, PD-L1, and has been shown to promote the production of PD-L1 in immune cells. This The interaction between SPAAR and PD-L1 has been shown to play a role in the development of cancer, as increased levels of PD-L1 have been linked to poor prognosis in cancer patients.

In addition to its role in immune regulation, SPAAR has also been shown to play a role in the regulation of cell signaling. SPAAR has been shown to interact with the protein, FAK, and has been shown to promote the phosphorylation of FAK. This interaction between SPAAR and FAK has been shown to play a role in the regulation of cellular processes, including cell adhesion, migration, and invasion.

SPAAR has also been shown to play a role in the regulation of inflammation. SPAAR has been shown to interact with the protein, NF-kappa-B, and has been shown to promote the production of pro-inflammatory cytokines. This interaction between SPAAR and NF-kappa-B has been shown to play a role in the regulation of inflammatory responses and the development of inflammatory diseases.

SPAAR has also been shown to play a role in the regulation of cell survival. SPAAR has been shown to interact with the protein, B-cell lymphoma 1 (Bcl-2), and has been shown to promote the phosphorylation of Bcl-2. This interaction between SPAAR and Bcl-2 has been shown to play a role in the regulation of cellular processes, including cell survival and proliferation.

In conclusion, SPAAR is a protein that has been identified as a potential drug target and biomarker for various diseases. Its unique structure and function have made it an attractive target for researchers to study, and its potential as a drug or biomarker has led to a growing interest in the field of neuroscience and immunology. Further research is needed to fully understand the role of SPAAR in various physiological processes and to determine its potential as a drug or biomarker.

Protein Name: Small Regulatory Polypeptide Of Amino Acid Response

Functions: Negative regulator of amino acid sensing and mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels and amino acids (PubMed:28024296). Negatively regulates mTORC1 activation by inhibiting recruitment of mTORC1 to lysosomes upon stimulation with amino acids: acts by promoting the formation of a tightly bound supercomplex composed of the lysosomal V-ATPase, Ragulator and Rag GTPases, preventing recruitment of mTORC1 (PubMed:28024296). Acts as a regulator of muscle regeneration following injury by regulating mTORC1 activation (By similarity)

The "SPAAR Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about SPAAR comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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