SorCS2: A Protein Involved in Multiple Cellular Processes (G57537)

Target Name: SORCS2

NCBI ID: G57537

SORCS2

SorCS2: A Protein Involved in Multiple Cellular Processes

SorCS2 (SorCBF2) is a protein that is expressed in various tissues throughout the body, including the brain, lungs, heart, kidneys, and intestines. It is a member of the superfamily of cytoplasmic proteins known as the small G-protein-coupled receptor (GPCR) family 2 (SORCS2). SorCS2 is characterized by a long extracellular domain that is rich in multiple charged and polar amino acids, as well as a short intracellular domain that is involved in protein-protein interactions.

The SORCS2 gene was identified in the genomic database using a combination of PCR and DNA sequencing techniques. The gene was later cloned into a plasmid and expressed in cell culture. The recombinant protein was purified and analyzed by a variety of techniques, including mass spectrometry, to determine its structure and function.

SorCS2 is a type of GPCR that is involved in the regulation of various cellular processes, including sensory perception, neurotransmitter signaling, and cell signaling pathways. It is characterized by a long extracellular domain that is involved in multiple cellular processes, including cell adhesion, migration, and invasion.

The intracellular domain of SorCS2 is a small protein that is involved in protein-protein interactions and may be involved in intracellular signaling pathways. The protein is known to interact with several other proteins, including the neurotransmitter receptor NG2 and the transcription factor p300. These interactions may play a role in the regulation of intracellular signaling pathways and the downstream effects of these pathways on cellular processes.

SorCS2 has been shown to be involved in a variety of cellular processes, including the regulation of neurotransmitter signaling, cell migration, and cell adhesion. For example, studies have shown that SorCS2 is involved in the regulation of the neurotransmitter receptor NG2, which is involved in pain perception and neurotransmission.

In addition to its role in neurotransmission, SorCS2 has also been shown to be involved in the regulation of cell adhesion and migration. For example, studies have shown that SorCS2 is involved in the regulation of cell adhesion to the plasma membrane, which is critical for the maintenance of tissue structure and the development of tissues.

SorCS2 has also been shown to be involved in the regulation of various signaling pathways, including T cell signaling pathways. For example, studies have shown that SorCS2 is involved in the regulation of the downstream effects of the T cell receptor, including the regulation of cell proliferation and apoptosis.

In addition to its role in cellular signaling pathways, SorCS2 has also been shown to be involved in the regulation of cellular processes related to cell survival and metabolism. For example, studies have shown that SorCS2 is involved in the regulation of cell survival and apoptosis, as well as the regulation of cellular metabolism and energy homeostasis.

Given its involvement in a variety of cellular processes, SorCS2 is a potential drug target or biomarker for a variety of diseases. For example, studies have shown that SorCS2 is involved in the regulation of pain perception and that inhibition of SorCS2 may be an effective treatment for pain. In addition, SorCS2 has also been shown to be involved in the regulation of neurotransmission, and inhibition of SorCS2 may be an effective treatment for neurotransmission disorders such as depression and anxiety.

In conclusion, SorCS2 is a protein that is characterized by a long extracellular domain that is rich in multiple charged and polar amino acids and a small intracellular domain that is involved in protein-protein interactions. It is a member of the SORCS2 family of GPCR proteins and is involved in a variety of cellular processes, including sensory perception, neurotransmission, cell adhesion, migration, and signaling pathways. Given its involvement in a variety of cellular processes, SorCS2 is a potential drug target or biomarker for a variety of diseases. Further research is needed to fully understand the role of SorCS2 in cellular processes and its potential as a drug.

Protein Name: Sortilin Related VPS10 Domain Containing Receptor 2

Functions: The heterodimer formed by NGFR and SORCS2 functions as receptor for the precursor forms of NGF (proNGF) and BDNF (proBDNF) (PubMed:22155786, PubMed:24908487). ProNGF and proBDNF binding both promote axon growth cone collapse (in vitro) (PubMed:22155786, PubMed:24908487). Plays a role in the regulation of dendritic spine density in hippocampus neurons (By similarity). Required for normal neurite branching and extension in response to BDNF (PubMed:27457814). Plays a role in BDNF-dependent hippocampal synaptic plasticity. Together with NGFR and NTRK2, is required both for BDNF-mediated synaptic long-term depression and long-term potentiation (PubMed:27457814). ProNGF binding promotes dissociation of TRIO from the heterodimer, which leads to inactivation of RAC1 and/or RAC2 and subsequent reorganization of the actin cytoskeleton (PubMed:22155786). Together with the retromer complex subunit VPS35, required for normal expression of GRIN2A at synapses and dendritic cell membranes. Required for normal expression of the amino acid transporter SLC1A1 at the cell membrane, and thereby contributes to protect cells against oxidative stress (By similarity)

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•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
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•   the target screening and validation;
•   expression level;
•   disease relevance;
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•   related combination drugs;
•   pharmacochemistry experiments;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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