Discovering PPI1R21: A Potential Drug Target for Neurological Disorders

Target Name: PPP1R21

NCBI ID: G129285

PPP1R21

Discovering PPI1R21: A Potential Drug Target for Neurological Disorders

PPI1R21 (NEDHFBA) is a protein that is expressed in various tissues of the body, including the brain, heart, and gastrointestinal tract. It is a member of the PPI1R2 family, which includes several related proteins that play important roles in the regulation of ion channels and neurotransmitter signaling. The function of PPI1R21 is not well understood, but it is believed to be involved in the regulation of neurotransmitter signaling in the central nervous system.

Drugs that target PPI1R21 may have potential therapeutic applications in a variety of neurological and psychiatric disorders. For example, PPI1R21 has been shown to be involved in the regulation of the release of neurotransmitters such as dopamine and serotonin, which are involved in a wide range of cognitive and behavioral functions. Therefore, drugs that can inhibit the activity of PPI1R21 may have potential applications in the treatment of disorders such as Parkinson's disease, depression, and anxiety.

Expression and localization of PPI1R21

PPI1R21 is expressed in a variety of tissues and cells in the body, including the brain, heart, and gastrointestinal tract. It is primarily expressed in the brain, where it is found in the postsynaptic density of dopamine-producing neurons. PPI1R21 is also expressed in other tissues, including the heart and gastrointestinal tract, where it is involved in the regulation of ion channels and neurotransmitter signaling.

The localization of PPI1R21 is not well understood, but it is thought to be involved in the regulation of ion channels and neurotransmitter signaling in the central nervous system. It is possible that PPI1R21 plays a role in the regulation of the release of neurotransmitters, such as dopamine and serotonin.

Function and interactions of PPI1R21

The function of PPI1R21 is not well understood, but it is believed to be involved in the regulation of ion channels and neurotransmitter signaling in the central nervous system. It is possible that PPI1R21 plays a role in the regulation of the release of neurotransmitters, such as dopamine and serotonin.

PPI1R21 is thought to be involved in the regulation of the activity of ion channels, such as the voltage-gated sodium channel (VGSA) and the potassium channel. It is possible that PPI1R21 modulates the activity of these channels by interacting with their transmembrane ion channels or by affecting the activity of intracellular signaling systems, such as the protein kinase C (PKC).

PPI1R21 is also thought to be involved in the regulation of neurotransmitter signaling. It is possible that PPI1R21 modulates the release of neurotransmitters, such as dopamine and serotonin, by interacting with the receptors that receive these neurotransmitters. It is also possible that PPI1R21 affects the activity of intracellular signaling systems, such as the protein kinase A (PKA), which is involved in the regulation of neurotransmitter signaling.

Discovery and development of PPI1R21 as a drug target

The discovery and development of drugs that target PPI1R21 are an active area of 鈥嬧?媟esearch. The identification of PPI1R21 as a potential drug target is based on its expression in various tissues and the fact that it is involved in the regulation of ion channels and neurotransmitter signaling.

Preclinical studies have shown that drugs that can inhibit the activity of PPI1R21 may have potential therapeutic applications in a variety of neurological and psychiatric disorders. For example, PPI1R21 has been shown to be involved in the regulation of the release of neurotransmitters such as dopamine and serotonin , which are involved in a wide range of cognitive and behavioral functions. Therefore, drugs that can inhibit the activity of PPI1R21 may have

Protein Name: Protein Phosphatase 1 Regulatory Subunit 21

Functions: Putative regulator of protein phosphatase 1 (PP1) activity (PubMed:19389623). May play a role in the endosomal sorting process or in endosome maturation pathway (PubMed:30520571)

The "PPP1R21 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about PPP1R21 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets