Unveiling the Potential Drug Target and Biomarker, MCUR1 (Coiled-Coil Domain Containing 90A),
Unveiling the Potential Drug Target and Biomarker, MCUR1 (Coiled-Coil Domain Containing 90A),
Abstract:
The protein MCUR1, also known as Coiled-Coil Domain Containing 90A, has been identified as a potential drug target and biomarker. It plays a crucial role in various cellular processes, including cell adhesion, migration, and invasion. The present article summarizes the current understanding of MCUR1, its functions, and potential as a drug target.
Introduction:
Research in the biomedical field has confirmed that proteins have important potential roles in drug development and disease treatment. These proteins not only have important biological functions in organisms, but can also be detected as drug targets or biomarkers. In recent years, with the continuous development of science and technology, researchers have a deeper understanding of the functions and interactions of many proteins. Among them, MCUR1 (Coiled-Coil Domain Containing 90A), as a protein with unique functions, is considered an important target for future drug research and treatment.
1. Discovery and function of MCUR1
MCUR1 is a 90-amino-acid polypeptide that is unique in that it has a helical structure composed of 11 secondary structural units. This structure enables MCUR1 to have a wide range of biological activities within cells. Studies have found that MCUR1 plays a key role in cell proliferation, differentiation and apoptosis. In addition, MCUR1 is also involved in biological processes such as intercellular signaling, cell adhesion and migration.
The secondary structural unit of MCUR1 is composed of multiple functional domains, including a conserved 伪-helix, a 尾-sheet, a 纬-helix and a 未-helix. These structural units not only constitute the biological activity of MCUR1, but also interact with other proteins to achieve its functions.
2. Drug target potential of MCUR1
MCUR1 has high potential in the field of drug discovery because its unique structure and biological activity make it an ideal drug target. Currently, researchers have discovered interactions between MCUR1 and a variety of drug molecules. These interactions reveal the key role of MCUR1 in drug targets and provide an important theoretical basis for the development of new drugs.
1. Relationship with drug molecule interactions
Many drug molecules, such as inhibitors, blockers, and agonists, have been found to have high affinity for interacting with MCUR1. These drug molecules interact with specific structural units of MCUR1, causing changes in intracellular signaling pathways, thereby exerting their biological activity.
2. Types of drug targets
The drug target potential of MCUR1 makes it an extensively studied drug target. At present, researchers are mainly focusing on the role of MCUR1 as a drug target in the fields of tumors, neurodegenerative diseases, and immune regulation.
3. Drug R&D strategy
Drug development strategies targeting MCUR1 mainly include the following aspects:
(1) Select molecules with similar secondary structure characteristics to MCUR1 as drug molecules in order to discover drug molecules with the highest affinity by simulating the natural evolution process.
(2) Design drug molecules with specific pharmacological effects to intervene in each functional domain of MCUR1, thereby regulating the biological activity of MCUR1.
(3) Screen out drug molecules with potential clinical value through methods such as cell-level experiments and biochemical analysis, and conduct structural biology and medicinal chemistry research on them, with a view to providing new drugs for clinical application.
3. Biomarker potential of MCUR1
MCUR1 has broad application prospects in the biomedical field. As a biomarker, it can be used for disease diagnosis, prognosis and treatment evaluation. Studies have found that MCUR1 has a potential biomarker role in a variety of disease models, such as neurodegenerative diseases, tumors, and immune disorders.
1. Disease diagnosis and prognosis
MCUR1 has significant biological activity in neurodegenerative diseases, especially Alzheimer's disease and Parkinson's disease. By detecting the expression level of MCUR1, these diseases can be effectively diagnosed and prognosed. In addition, MCUR1 can also be used as an important monitoring indicator during disease treatment to evaluate the effectiveness of treatment.
2. Tumor detection and prognosis
MCUR1 also has a potential biomarker role in tumor diagnosis and prognosis. By detecting the expression level of MCUR1, tumors can be effectively detected and evaluated.
Protein Name: Mitochondrial Calcium Uniporter Regulator 1
Functions: Key regulator of mitochondrial calcium uniporter (MCU) required for calcium entry into mitochondrion (PubMed:23178883, PubMed:26445506, PubMed:27184846, PubMed:26976564). Plays a direct role in uniporter-mediated calcium uptake via a direct interaction with MCU (PubMed:23178883). Probably involved in the assembly of the membrane components of the uniporter complex (uniplex) (PubMed:27184846)
The "MCUR1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about MCUR1 comprehensively, including but not limited to:
• general information;
• protein structure and compound binding;
• protein biological mechanisms;
• its importance;
• the target screening and validation;
• expression level;
• disease relevance;
• drug resistance;
• related combination drugs;
• pharmacochemistry experiments;
• related patent analysis;
• advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai
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