MTMR14 Variant 2: Potential Therapeutic Target for Neurodegeneration, Diabetes, Obesity and Inflammation

Target Name: MTMR14

NCBI ID: G64419

MTMR14

MTMR14 Variant 2: Potential Therapeutic Target for Neurodegeneration, Diabetes, Obesity and Inflammation

MTMR14, also known as MTMR14 variant 2, is a protein that is expressed in various tissues of the body, including the brain, heart, and kidneys. It is a member of the Mitchell family of glycoproteins , plays an important role in the diagnosis and treatment of many diseases.

MTMR14 variant 2 is a single-chain alternatively spliced 鈥嬧?媝rotein whose encoding gene is located in the proximal region of the long arm of human chromosome 14. The protein is a single-chain molecule composed of 94 amino acids and has a molecular weight of 11.9 kDa. MTMR14 variant 2 is expressed in a variety of tissues and organs, including the brain, heart, pancreas, adrenal glands, and uterus.

The role and significance of MTMR14 variant 2 in disease remains an open question. However, research shows that this protein plays an important role in a variety of diseases, such as neurodegeneration, diabetes, obesity, and inflammation.

First, MTMR14 variant 2 is associated with neurodegenerative diseases. Neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, and Huntington's disease are associated with neuronal damage and death. The role of MTMR14 variant 2 in neuronal damage and neuronal death remains an open question. Research shows that loss of MTMR14 variant 2 leads to neuronal damage and neuronal death, thereby increasing the risk of neurodegenerative diseases.

Secondly, MTMR14 variant 2 is associated with diabetes. Diabetes is a metabolic disease caused by insufficient insulin secretion or reduced cell sensitivity to insulin. The role of MTMR14 variant 2 in diabetes remains an open question. Studies have shown that deletion of MTMR14 variant 2 can lead to the occurrence and progression of diabetes, thereby making it more difficult to treat diabetes.

In addition, MTMR14 variant 2 is associated with obesity and inflammation. Obesity and inflammatory diseases such as cardiovascular disease and rheumatoid arthritis are associated with obesity and inflammation. The role of MTMR14 variant 2 in obesity and inflammatory diseases remains an open question. Research shows that loss of MTMR14 variant 2 increases the risk of obesity and inflammatory diseases.

As a protein, the role and significance of MTMR14 variant 2 in disease remain to be further studied.

Protein Name: Myotubularin Related Protein 14

Functions: Lipid phosphatase which efficiently dephosphorylates phosphatidylinositol 3-phosphate (PtdIns3P) and PtdIns(3,5)P2; inactive toward PtdIns4P, PtdIns(3,4)P2, PtdIns(4,5)P2 and PtdIns(3,4,5)P3

The "MTMR14 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about MTMR14 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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