TYRO3: Key Regulator of Cell Proliferation and Survival (G7301)

Target Name: TYRO3

NCBI ID: G7301

TYRO3

TYRO3: Key Regulator of Cell Proliferation and Survival

TYRO3 (tyrosine-protein kinase SKY) is a protein that is expressed in various tissues throughout the body, including the brain, heart, and kidneys. It is a key regulator of cell proliferation and has been implicated in a number of diseases, including cancer, neurodegenerative diseases, and autoimmune disorders.

One of the key functions of TYRO3 is its role as a protein kinase, which means it can catalyze the transfer of a phosphate group from another protein to itself. This process is important for the regulation of cell growth, differentiation, and survival, and is a key mechanism underlying many diseases.

In addition to its role as a protein kinase, TYRO3 is also known for its role as a negative regulator of the TGF-β pathway, which is a signaling pathway that is involved in cell growth, differentiation, and survival. TGF-β is a potent regulator of cell proliferation and has been implicated in a number of diseases, including cancer, neurodegenerative diseases, and autoimmune disorders.

The TGF-β pathway is activated by various signals, including the presence of mechanical stress, growth factors, and intracellular signaling molecules. When TGF-β is activated, it causes the cell to enter a state of increased sensitivity to these signals, which can lead to cell proliferation and the development of cancer.

To learn more about TYRO3 and its role in the TGF-β pathway, it is important to understand more about the structure and function of this protein. TYRO3 is a 21-kDa protein that consists of 218 amino acid residues. It has a unique structure, with a catalytic active site at its N-terminus and a N-cadherin-like domain at its C-terminus.

The N-cadherin-like domain is a unique feature of TYRO3, as it is not typically found in proteins that are involved in the TGF-β pathway. This domain is thought to play a key role in TYRO3's ability to regulate the TGF-β pathway, as it is able to interact with and inhibit the activity of the protein TGF-β.

In addition to its role in regulating the TGF-β pathway, TYRO3 is also involved in the regulation of cell proliferation and has been implicated in a number of diseases. For example, TYRO3 has been shown to be involved in the regulation of cell cycle progression, and has been shown to play a role in the development of cancer.

In addition to its role in cell proliferation, TYRO3 is also involved in the regulation of cell survival. This is evident from the fact that TYRO3 has been shown to play a role in the regulation of apoptosis, which is the process by which cells undergo programmed cell death.

The regulation of apoptosis is important for the development and progression of diseases, as it helps to remove damaged or dysfunctional cells from the body. However, TYRO3 is also involved in the regulation of pro-survival signaling pathways, which are involved in the regulation of cell survival.

In conclusion, TYRO3 is a protein that is involved in a number of important processes in the regulation of cell proliferation and survival. Its unique structure and function, as well as its involvement in the regulation of the TGF-β pathway, make it an attractive target for research and potential therapeutic development. As more research is conducted on TYRO3, it is likely that its role in the regulation of cell biology will become increasingly important for the understanding and treatment of a wide range of diseases.

Protein Name: TYRO3 Protein Tyrosine Kinase

Functions: Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including TULP1 or GAS6. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of TYRO3 on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with PIK3R1 and thereby enhances PI3-kinase activity. Activates the AKT survival pathway, including nuclear translocation of NF-kappa-B and up-regulation of transcription of NF-kappa-B-regulated genes. TYRO3 signaling plays a role in various processes such as neuron protection from excitotoxic injury, platelet aggregation and cytoskeleton reorganization. Also plays an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3

The "TYRO3 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about TYRO3 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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