NAMPTP1: Regulating DNA Binding and Gene Expression (G646309)

Target Name: NAMPTP1

NCBI ID: G646309

NAMPTP1

NAMPTP1: Regulating DNA Binding and Gene Expression

NAMPTP1 (Nucleotide-binding adaptor protein 1) is a protein that plays a crucial role in the regulation of DNA binding and gene expression. It is a member of the NAMPTP family, which includes several related proteins that regulate nucleotide binding and protein-DNA interactions. NAMPTP1 is widely expressed in various tissues and cells, and it has been implicated in several cellular processes, including DNA replication, transcription, and repair.

One of the unique features of NAMPTP1 is its ability to interact with specific DNA sequences. It has been shown to form a complex with the nucleotide GDP and the protein TFII-1, which are involved in the regulation of DNA binding and gene expression, respectively. This interaction between NAMPTP1 and TFII-1 allows NAMPTP1 to regulate the activity of TFII-1 and enhance its DNA-binding capacity.

In addition to its role in regulating TFII-1 activity, NAMPTP1 has also been shown to play a role in the regulation of DNA replication. It has been shown to interact with the protein p16, which is involved in the regulation of DNA replication initiation. This interaction between NAMPTP1 and p16 allows NAMPTP1 to regulate the activity of p16 and enhance its ability to promote DNA replication.

NAMPTP1 has also been shown to play a role in the regulation of gene expression. It has been shown to interact with the protein Stat3, which is involved in the regulation of DNA binding and gene expression. This interaction between NAMPTP1 and Stat3 allows NAMPTP1 to regulate the activity of Stat3 and enhance its ability to promote gene expression.

In conclusion, NAMPTP1 is a protein that plays a crucial role in the regulation of DNA binding and gene expression. Its interaction with TFII-1 and p16 allows it to regulate the activity of these proteins and enhance its ability to promote DNA replication and gene expression. As a potential drug target or biomarker, NAMPTP1 is a promising target for the development of new therapies for a variety of diseases.

Protein Name: Nicotinamide Phosphoribosyltransferase Pseudogene 1

The "NAMPTP1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about NAMPTP1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
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•   the target screening and validation;
•   expression level;
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•   related combination drugs;
•   pharmacochemistry experiments;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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