NBAT1: A Potential Drug Target and Biomarker (G729177)

Target Name: NBAT1

NCBI ID: G729177

NBAT1

Other Name(s): NBAT-1 | Neuroblastoma associated transcript 1 | CASC14 | neuroblastoma associated transcript 1 | FLJ44180

NBAT1: A Potential Drug Target and Biomarker

Non-coding RNA (ncRNA) have been identified as key regulators of gene expression in various organisms, including humans. One of the well-known ncRNA is NBAT1 (Nuclear Button-Activated Transcript 1), which has been shown to play a critical role in various cellular processes in the brain. NBAT1 has also been implicated in the development and progression of neurological disorders, making it an attractive drug target and biomarker. In this article, we will discuss the potential of NBAT1 as a drug target and biomarker, as well as its current state in research.

NBAT1: Structure and Function

NBAT1 is a non-coding RNA molecule that was identified by bioinformatic analysis of RNA-seq data from the brain. NBAT1 is expressed in various tissues and cells of the brain, including neurons, glial cells, and microglia. It is highly expressed in the brains of individuals with Alzheimer's disease, Parkinson's disease, and other neurological disorders.

NBAT1 is involved in the regulation of gene expression by binding to specific DNA sequences. It functions as a transcription factor, which can activate gene transcription when bound to a DNA template. NBAT1 has been shown to play a role in the regulation of neurotransmitter synthesis and release, and in the modulation of pain perception.

In addition to its role in gene expression, NBAT1 has also been shown to play a critical role in the regulation of cellular signaling pathways. It has been shown to interact with various protein partners, including the neurotransmitter acetylcholine, which is involved in the regulation of memory and learning.

NBAT1 as a Drug Target

The potential of NBAT1 as a drug target is based on its involvement in various cellular processes that are implicated in the development and progression of neurological disorders. NBAT1 has been shown to be involved in the regulation of neurotransmitter synthesis and release, which is a key factor in the development of disorders such as Alzheimer's disease and Parkinson's disease.

In addition, NBAT1 has also been shown to play a role in the regulation of pain perception, which is another important factor in the development of neurological disorders. NBAT1 has been shown to interact with the neurotransmitter GABA, which is involved in the regulation of pain perception.

Currently, there are several NBAT1-targeted drugs in development that are aimed at treating neurological disorders. These drugs include small molecules that can inhibit the activity of NBAT1, as well as RNA-based therapeutics that can specifically target NBAT1.

NBAT1 as a Biomarker

NBAT1 has also been shown to be a potential biomarker for the diagnosis and progression of neurological disorders. The levels of NBAT1 have been shown to be decreased in the brains of individuals with Alzheimer's disease and Parkinson's disease, which are two of the most common neurological disorders.

In addition, NBAT1 has also been shown to be involved in the regulation of gene expression in the brain, which can be used as a biomarker for the diagnosis of neurodegenerative disorders. For example, NBAT1 has been shown to be involved in the regulation of the expression of genes involved in neurotransmitter synthesis and release, which can be used as a biomarker for the diagnosis of Alzheimer's disease.

Conclusion

NBAT1 is a non-coding RNA molecule that has been shown to play a critical role in various cellular processes in the brain. Its functions as a transcription factor and its interaction with various protein partners make NBAT1 an attractive drug target and biomarker. Currently, there are several NBAT1-targeted drugs in development, as well as RNA-based therapeutics that are aimed at treating NBAT1-related disorders. Further research is needed to fully understand the role of NBAT1 in the development and progression of neurological disorders, as well as its potential as a biomarker

Protein Name: Neuroblastoma Associated Transcript 1

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•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
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•   the target screening and validation;
•   expression level;
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•   pharmacochemistry experiments;
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The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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