NAV3: A Potential Drug Target and Biomarker (G89795)

Target Name: NAV3

NCBI ID: G89795

NAV3

NAV3: A Potential Drug Target and Biomarker

NAV3 (N-acetyl-尾-glutamyl-L-histidine) is a protein that is expressed in various tissues of the body, including the brain, heart, and kidneys. It is a member of the histidine acetyltransferase family 3 (HAT3) and is involved in the regulation of cellular processes such as cell adhesion, migration, and signaling pathways.

NAV3 has been identified as a potential drug target or biomarker due to its unique structure and the involvement of various cellular processes. One of the key advantages of NAV3 is its ability to interact with various signaling molecules, including the neurotransmitter serotonin. This interaction suggests that NAV3 could be a useful target for drugs that are designed to modulate serotonin signaling in neural circuits.

In addition to its potential as a drug target, NAV3 has also been shown to be a valuable biomarker for various neurological and psychiatric disorders. For example, NAV3 has been shown to be elevated in individuals with major depressive disorder (MDD) and anxiety disorders, and has been used as a diagnostic marker for these conditions in clinical trials.

The unique structure of NAV3 also makes it an attractive target for small molecules that can modulate its activity. One of the first compounds to be shown to interact with NAV3 was the drug Nabumetone, a non-steroidal anti- Inflammatory drugs (NSAIDs) can mimic the mechanism of action of non-steroidal anti-inflammatory drugs and reduce pain and inflammation by inhibiting the activity of cyclooxygenase (COX).

In addition, because NAV3 plays a role in a variety of physiological processes, it also has broad application prospects in drug development. For example, using NAV3 as a drug target could lead to the development of drugs that regulate neuronal growth and synaptic plasticity, as well as treatments for neurodegenerative diseases such as Alzheimer's disease.

In summary, NAV3, as a protein with unique structure and function, is considered a drug target or biomarker worthy of attention and research. With the continuous development of science and technology, it is expected to bring new methods and hope for the treatment of various neurological diseases in the future.

Protein Name: Neuron Navigator 3

Functions: Plays a role in cell migration (PubMed:21471154). May be involved in neuron regeneration. May regulate IL2 production by T-cells

The "NAV3 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about NAV3 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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