NAPRT: An Enzyme for DNA Repair and Replication (G93100)

Target Name: NAPRT

NCBI ID: G93100

NAPRT

NAPRT: An Enzyme for DNA Repair and Replication

NAPRT (NAD+-dependent RNA polymerase) is an enzyme that plays a crucial role in the regulation of DNA replication and repair in various organisms, including humans. NAPRT is a protein that is expressed in most cell types of the body and is involved in the repair of DNA damage caused by various factors, including radiation, chemicals, and mutations.

NAPRT is a nucleotide-binding enzyme that uses NAD+ as a cofactor to initiate the DNA replication process. The NAD+ molecule is a crucial cofactor for the enzyme because it provides a structural base for the enzyme to bind to the DNA template. also an electron carrier, which means it can transfer electrons to other molecules. This electron transfer allows the enzyme to bind to the DNA template and initiate the replication process.

One of the unique features of NAPRT is its ability to repair DNA damage caused by different types of stressors. For example, NAPRT can repair DNA damage caused by radiation, such as ionizing radiation, as well as DNA damage caused by other types of stressors, such as chemical stressors and mechanical stressors. This ability makes NAPRT an important enzyme for DNA repair in various organisms.

In addition to its role in DNA repair, NAPRT is also involved in the regulation of DNA replication. NAPRT is a negative regulator of DNA replication, which means it works to prevent the excessive replication of DNA that can occur during the repair process. This helps to maintain the integrity of the genetic material and prevent the development of cancer.

NAPRT is also involved in the regulation of cell cycle progression. NAPRT is a component of the G1 phase of the cell cycle, which is the stage of cell growth and preparation for cell division. During the G1 phase, NAPRT helps to regulate the entry of new DNA into the cell and the progression of the cell through the DNA replication cycle. This helps to ensure that the cell has enough DNA for proper cell division and growth.

Another important function of NAPRT is its role in the regulation of gene expression. NAPRT is a negative regulator of gene expression, which means it works to prevent the excessive expression of certain genes. This helps to maintain the balance of gene expression in the cell and prevent the development of cancer.

NAPRT is also involved in the regulation of cellular stress. NAPRT is a stress-sensitive enzyme, which means that it is sensitive to various types of stressors, such as temperature, pH, and radiation. This sensitivity allows NAPRT to function as a stress sensor and help to protect the cell from cellular stress.

In conclusion, NAPRT is a crucial enzyme that plays a vital role in the regulation of DNA replication and repair in various organisms. NAPRT's ability to repair DNA damage caused by different types of stressors makes it an important enzyme for DNA repair in the cell. Additionally , NAPRT's role in regulating DNA replication, cell cycle progression, gene expression, and cellular stress make it a valuable target for researchers who are interested in understanding the mechanisms of DNA repair and replication in various organisms.

Protein Name: Nicotinate Phosphoribosyltransferase

Functions: Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate (PubMed:17604275, PubMed:21742010, PubMed:26042198). Helps prevent cellular oxidative stress via its role in NAD biosynthesis (PubMed:17604275)

The "NAPRT Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about NAPRT comprehensively, including but not limited to:
•   general information;
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•   protein biological mechanisms;
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•   the target screening and validation;
•   expression level;
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•   related combination drugs;
•   pharmacochemistry experiments;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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