NBR1: A Potential Drug Target and Biomarker for the Treatment of Chronic Pain

Target Name: NBR1

NCBI ID: G4077

NBR1

NBR1: A Potential Drug Target and Biomarker for the Treatment of Chronic Pain

Abstract:

Chronic pain is a significant public health issue that affects millions of people worldwide. The failure of current pain treatments to provide long-lasting relief and the increasing burden on healthcare systems have led to the need for new and innovative approaches to pain management. The NBR1 gene, located on chromosome 6, has been identified as a potential drug target and biomarker for the treatment of chronic pain. In this article, we will review the current research on NBR1 and its potential as a drug target and biomarker for the treatment of chronic pain.

Introduction:

Chronic pain is a persistent and often debilitating condition that can have significant impacts on an individual's quality of life and overall health. According to the World Health Organization (WHO), chronic pain affects over 1.1 billion people worldwide, with 50% of the population reporting chronic pain. The causes of chronic pain are varied and can include musculoskeletal, neuropathic, and psychiatric conditions. Despite the availability of treatments for some types of chronic pain, the lack of effective pain relief remains a significant challenge for patients and healthcare systems.

The NBR1 gene:

The NBR1 gene, located on chromosome 6, has been identified as a potential drug target and biomarker for the treatment of chronic pain. The NBR1 gene encodes a protein known as NBR1, which is a non-protein kinase B (NPI) that plays a role in the regulation of pain signaling. NBR1 has been shown to regulate the activity of several pain-related genes, including TrkA, TrkB, and TrkC, which encode for proteins involved in pain perception and neurotransmitter release.

In addition to its role in pain regulation, NBR1 has also been shown to play a role in the development and maintenance of chronic pain. For example, NBR1 has been shown to promote the formation of pain-perceiving neurons in the central nervous system, which can lead to the development of chronic pain. Additionally, NBR1 has been shown to enhance the release of pain-related neurotransmitters, such as opioids, which can further contribute to the development of chronic pain.

As a drug target:

The NBR1 gene has the potential to be a drug target for the treatment of chronic pain due to its role in pain regulation and the development of chronic pain. Several studies have shown that inhibiting NBR1 activity can provide relief from chronic pain in animal models. For example, inhibition of NBR1 has been shown to decrease pain behavior in rat models of neuropathic pain and opioid-induced pain.

In addition to its potential as a drug target, NBR1 has also been identified as a potential biomarker for the treatment of chronic pain. The NBR1 gene has been shown to be expressed in the central nervous system and has been detected in various types of chronic pain, including neuropathic pain and cancer-induced pain. Additionally, NBR1 has been shown to be associated with the development of chronic pain in humans, with higher levels of NBR1 expression being associated with greater pain severity and disability.

As a biomarker:

The NBR1 gene has also been identified as a potential biomarker for the treatment of chronic pain. The NBR1 gene has been shown to be expressed in the central nervous system and has been detected in various types of chronic pain, including neuropathic pain and cancer-induced pain. Additionally, NBR1 has been shown to be associated with the development of chronic pain in humans, with higher levels of NBR1 expression being associated with greater pain severity and disability.

The potential utility of NBR1 as a biomarker for the treatment of chronic pain is derived from its role in pain regulation and its association with the development of chronic pain in humans. The use of NBR1 as a biomarker for the diagnosis and treatment of chronic pain is an promising approach with the potential to improve the quality of life for patients.

Conclusion:

In conclusion, the NBR1 gene has been identified as a potential drug target and biomarker for the treatment of chronic pain. The NBR1 gene has been shown to regulate pain signaling and has been associated with the development of chronic pain in both animals and humans. Further research is needed to

Protein Name: NBR1 Autophagy Cargo Receptor

Functions: Ubiquitin-binding autophagy adapter that participates in different processes including host defense or intracellular homeostasis (PubMed:33577621, PubMed:24692539). Possesses a double function during the selective autophagy by acting as a shuttle bringing ubiquitinated proteins to autophagosomes and also by participating in the formation of protein aggregates (PubMed:24879152, PubMed:34471133). Plays a role in the regulation of the innate immune response by modulating type I interferon production and targeting ubiquitinated IRF3 for autophagic degradation (PubMed:35914352). In response to oxidative stress, promotes an increase in SQSTM1 levels, phosphorylation, and body formation by preventing its autophagic degradation (By similarity). In turn, activates the KEAP1-NRF2/NFE2L2 antioxidant pathway (By similarity). Plays also non-autophagy role by mediating the shuttle of IL-12 to late endosome for subsequent secretion (By similarity)

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•   expression level;
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The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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